Academic Radiology
Volume 13, Issue 1 , Pages 4-13 , January 2006

Assessment of Unspecific Near-Infrared Dyes in Laser-Induced Fluorescence Imaging of Experimental Arthritis

  • Thomas Fischer, MD

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • Corresponding Author InformationAddress correspondence to: T.F Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Ines Gemeinhardt, DVM

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Susanne Wagner, DVM

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Dorothee v. Stieglitz, DVM

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Jörg Schnorr, DVM

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Kay-Geert A. Hermann, MD

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Bernd Ebert, PhD

      Affiliations

    • Physikalisch-Technische Bundesanstalt, Department of Biomedical Optics
    • ,
  • Diethard Petzelt

      Affiliations

    • Physikalisch-Technische Bundesanstalt, Department of Biomedical Optics
    • ,
  • Rainer MacDonald, PhD

      Affiliations

    • Physikalisch-Technische Bundesanstalt, Department of Biomedical Optics
    • ,
  • Kai Licha, PhD

      Affiliations

    • Schering AG, Research Laboratories, Berlin, Germany
    • ,
  • Michael Schirner, MD

      Affiliations

    • Schering AG, Research Laboratories, Berlin, Germany
    • ,
  • Veit Krenn, MD

      Affiliations

    • Department of Pathology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Thomas Kamradt, MD

      Affiliations

    • Department of Rheumatology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany
    • ,
  • Matthias Taupitz, MD, PhD

      Affiliations

    • Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstrasse 20/21, 10098 Berlin, Germany

Received 27 May 2005 ,Revised 14 July 2005 ,Accepted 18 July 2005.

References 

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  2. Backhaus M , Kamradt T , Sandrock D , et al.   Arthritis of the finger joints. A comprehensive approach comprising conventional radiology, scintigraphy, ultrasound, and contrast-enhanced MR imaging . Arthritis Rheum . 1999;42:1232–1245
  3. Mohr W . Pathogenese der Gelenkzerstörung bei der chronischen Polyarthritis . Radiologe . 1996;36:593–599
  4. Bollow M , Fischer T , Reisshauer H , et al.   Quantitative analyses of sacroiliac biopsies in spondyloarthropathies (T cells and macrophages predominate in early and active sacroiliitis—cellularity correlates with the degree of enhancement detected by magnetic resonance imaging) . Ann Rheum Dis . 2000;59:135–140
  5. Ebert B , Sukowski U , Grosenick D , et al.   Near-infrared fluorescent dyes for enhanced contrast in optical mammography (phantom experiments) . J Biomed Optics . 2001;6:134–140
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  8. Riefke B , Licha K , Nolte D , et al.   Tumor detection with cyanine dye-poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging. Optical and imaging techniques for biomonitoring III . SPIE . 1997;3196:103–110
  9. Licha K . Contrast agents for optical imaging (review) . In:  Krause W editors. Topics in Current Chemistry—Contrast Agents II . Vol 222: Heidelberg: Springer; 2002;p. 1–31
  10. Licha K , Riefke B , Ntziachristos V , et al.   Hydrophilic cyanine dye as contrast agents for near-infrared tumor imaging (synthesis, photophysical properties and spectroscopic in vivo characterisation) . Photochem Photobiol . 2000;72:392–398
  11. Prapavat V , Runge W , Mans J , et al.   Entwicklung eines Fingergelenkphantomes zur optischen Simulation früher entzündlich-rheumatischer Veränderungen . Biomed Technik . 1997;42:319–326
  12. Scheel AK , Krause A , Mesecke-von Rheinbaben I , et al.   Assessment of proximal finger joint inflammation in patients with rheumatoid arthritis, using a novel laser-based imaging technique . Arthritis Rheum . 2002;46:1177–1184
  13. Wunder A , Tung CH , Muller-Ladner U , et al.   In vivo imaging of protease activity in arthritis (a novel approach for monitoring treatment response) . Arthritis Rheum . 2004;50:2459–2465
  14. Hansch A , Frey O , Sauner D , et al.   In vivo imaging of experimental arthritis with near-infrared fluorescence . Arthritis Rheum . 2004;50:961–967
  15. Becker A , Riefke B , Ebert B , et al.   Macromolecular contrast agents for optical imaging of tumors (comparison of indotricarbocyanine-labeled human serum albumin and transferrin) . Photochem Photobiol . 2000;71:234–241
  16. Cherrick GR , Stein SW , Leevy CM , et al.   Indocyanine green (observations on its physical properties, plasma decay and hepatic extraction) . J Clin Invest . 1960;39:592–600
  17. Warner GS . Laboratory Animal Toxicity Studies on Cardiogreen. Documentation of Hynson . Baltimore, MD: Weskott & Dunning; 1971;
  18. Licha K , Riefke B , Semmler W . Synthesis and characterization of cyanine dye–poly(ethylene glycol) conjugates as contrast agents for in vivo fluorescence imaging . SPIE . 1997;3196:98–102
  19. Riefke B , Licha K , Semmler W . In vivo characterization of cyanine dyes as contrast agents for near-infrared imaging . SPIE . 1996;2927:199–208
  20. Schaible UE , Kramer MD , Wallich R , et al.   Experimental Borrelia burgdorferi infection in inbred mouse strains (antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis) . Eur J Immunol . 1991;21:2397–2405
  21. Kamradt T . Lyme disease and current aspects of immunization . Arthritis Res . 2002;4:20–29
  22. Pennington PM , Allred CD , West CS , et al.   Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease . Infect Immun . 1997;65:285–292
  23. Bremer C , Ntziachristos V , Weissleder R . Optical-based molecular imaging (contrast agents and potential medical applications) . Eur Radiol . 2003;13:231–243

PII: S1076-6332(05)00644-6

doi: 10.1016/j.acra.2005.07.010

Academic Radiology
Volume 13, Issue 1 , Pages 4-13 , January 2006

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