Academic Radiology
Volume 13, Issue 6 , Pages 721-727 , June 2006

Inversion Recovery MRI in Idiopathic Parkinson Disease Is a Very Sensitive Tool to Assess Neurodegeneration in the Substantia Nigra: Preliminary Investigation

  • Ulrich Raff, PhD

      Affiliations

    • Department of Physics, University of Santiago de Chile, Avda Ecuador 3493, Santiago, Chile
    • Corresponding Author InformationAddress correspondence to: U.R.
  • ,
  • Michael Hutchinson, PhD, MD

      Affiliations

    • Department of Neurology, New York University School of Medicine, New York, NY
  • ,
  • Gonzalo M. Rojas, BS

      Affiliations

    • Department of Physics, University of Santiago de Chile, Avda Ecuador 3493, Santiago, Chile
  • ,
  • Isidro Huete, MD

      Affiliations

    • Department of Radiology, Catholic University of Chile, Santiago, Chile.

Received 15 December 2005 ,Revised 12 January 2006 ,Accepted 15 January 2006.

References 

  1. Parkinson J . An essay on the shaking palsy . London: Whittingham & Rowland; 1817;
  2. Lang AE , Lozano AM . Parkinson’s disease. First of two parts . N Engl J Med . 1998;339:1044–1053
  3. Lang AE , Lozano AM . Parkinson’s disease. Second of two parts . N Engl J Med . 1998;339:1130–1143
  4. Hutchinson M , Raff U . Parkinson’s disease (a novel MRI method for determining the structural changes in the substantia nigra) . J Neurol Neurosurg Psychiatr . 1999;67:815–818
  5. Hutchinson M , Raff U . Structural changes in the substantia nigra in Parkinson’s disease as revealed by MR imaging . AJNR Am J Neuroradiol . 2000;21:697–701
  6. Hutchinson M , Raff U , Lebedev S . MRI correlates of pathology in parkinsonism (segmented inversion recovery ratio imaging (SIRRIM)) . NeuroImage . 2003;20:1899–1902
  7. Raff U , Rojas GM , Huete I , Hutchinson M . Computer assessment of neurodegeneration in Parkinson disease using data fusion techniques with MR images . Acad Radiol . 2003;10:1036–1044
  8. Fahn S , Elton ER . Unified Parkinson’s disease rating scale . In:  Fahn S ,  Marsden CD ,  Calne D ,  Goldstein M editor. Recent Developments in Parkinson’s Disease . 2: London: Macmillan; 1987;p. 293–304
  9. Biomarkers Definitions Working Group . Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Commentary . Bethesda, Md Clin Pharmacol Ther . 2001;69:89–95
  10. Shinotoh H , Calne DB . The use of PET in Parkinson’s disease . Brain Cogn . 1995;28:297–301
  11. Sawle GV , Playford ED , Burn DJ , et al.   Separating Parkinson’s disease from normality. Discriminant function analysis of fluorodopa F18 positron emission tomography data . Arch Neurol . 1994;51:237–243
  12. Sawle GV . The detection of preclinical Parkinson’s disease (what is the role of positron emission tomography?) . Mov Disord . 1993;8:271–277
  13. Hu MT , White SJ , Herlihy AH , Chaudhuri KR , Hajnal JV , Brooks DJ . A comparison of 18F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson’s disease . Neurology . 2001;56:1195–1200
  14. Piccini P , Brooks DJ . Etiology of Parkinson’s disease (contributions from 18F-DOPA positron emission tomography) . Adv Neurol . 1999;80:227–231
  15. Marek K , Innis R , van Dyck C , et al.   [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression . Neurology . 2001;57:2089–2094
  16. Mauricio JC , Coelho H , Sa J , Martins A . Importance of magnetic resonance in Parkinson disease. An analytic study of the pars compacta . Acta Med Port . 1990;3:85–88
  17. Stern MB , Braffman BH , Skolnick BE , Hurtig HI , Grossman RI . Magnetic resonance imaging in Parkinson’s disease and parkinsonian syndromes . Neurology . 1989;39:1524–1526
  18. Gorell JM , Ordidge RJ , Brown GG , Deniau JC , Buderer NM , Helpern JA . Increased iron-related MRI contrast in the substantia nigra in Parkinson’s disease [published erratum in Neurology 1995; 45:1420] . Neurology . 1995;45:1138–1143
  19. Antonini A , Leenders KL , Meier D , Oertel WH , Boesiger P , Anliker M . T2 relaxation time in patients with Parkinson’s disease . Neurology . 1993;43:697–700
  20. Moriwaka F , Tashiro K , Itoh K , Hamada T , Miyasaka K . Magnetic resonance imaging in Parkinson’s disease—the evaluation of the width of the substantia pars compacta on T2 weighted images . Rinsho Shinkeigaku . 1992;32:8–12
  21. Tou JT , Gonzalez RC . Pattern classification by distance functions . In: Pattern Recognition Principles. Edition 1981 (revived and scanned version) . Boston, MA: Addison-Wesley; 1999;p. 94–97
  22. Fearnley JM , Lees AJ . Aging and Parkinson’s disease (substantia nigra regional selectivity) . Brain . 1991;114:2283–2301
  23. Damier P , Hirsch EC , Agid Y , Graybiel AM . The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D28K immunohistochemistry . Brain . 1999;122:1421–1436
  24. Damier P , Hirsch EC , Agid Y , Graybiel AM . The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson’s disease . Brain . 1999;122:1437–1448
  25. Porter T , Duff T . Compositing digital images . Comp Graphics . 1984;18:253–259
  26. Duvoisin RC . Familial Parkinson’s disease . Neurosci News . 1998;1:43–46
  27. Gasser T . Is Parkinson’s disease an inherited condition? . Adv Neurol . 1999;80:143–152
  28. Koller W , Vetere-Overfield B , Gray C , et al.   Environmental risk factors in Parkinson’s disease . Neurology . 1990;40:1218–1221
  29. De Michele G , Filla A , Volpe G , et al.   Environmental and genetic risk factors in Parkinson’s disease (a case-control study in southern Italy) . Mov Disord . 1996;11:17–23
  30. Hu MT , Scherfler C , Khan NL , et al.   Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and parkin-linked Parkinson’s disease . Mov Disord . 2006;20(21):299–305
  31. The Parkinson Study Group . Levodopa and the progression of Parkinson’s disease . N Engl J Med . 2004;351:2498–2508

1 This study was supported in part by the Myra Fox and Max Smedresman Funds for Research into Parkinson’s disease (NYU School of Medicine; M.H., U.R.) and partial support from the DICYT of the University of Santiago de Chile (grant 020531RB).

PII: S1076-6332(06)00078-X

doi: 10.1016/j.acra.2006.01.049

Academic Radiology
Volume 13, Issue 6 , Pages 721-727 , June 2006