Academic Radiology
Volume 13, Issue 6 , Pages 686-693 , June 2006

Theory-Based Signal Calibration with Single-Point T1 Measurements for First-Pass Quantitative Perfusion MRI Studies

  • Alexandru Cernicanu, PhD

      Affiliations

    • Electrical and Systems Engineering, University of Pennsylvania, 200 South 33rd Street, Philadelphia, PA 19104
    • Corresponding Author InformationAddress correspondence to: A.C.
    • ,
  • Leon Axel, MD, PhD

      Affiliations

    • Department of Radiology, NYUMC, 650 First Avenue, Room 600A, New York, NY 10016

Received 23 December 2005 ,Revised 7 February 2006 ,Accepted 10 February 2006.

References 

  1. Jerosch-Herold M , Wilke N , Stillman AE , Wilson RF . Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution . Med Phys . 1998;25:73–84
  2. Vallee J , Lazeyras F , Kasuboski L , et al.   Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function . J Magn Reson Imaging . 1999;9:197–203
  3. Deichmann R , Hahn D , Haase A . Fast T1 mapping on a whole-body scanner . Magn Reson Med . 1999;42:206–209
  4. Ding S , Wolff S , Epstein F . Improved coverage in dynamic contrast-enhanced cardiac MRI using interleaved gradient-echo EPI . Magn Reson Med . 1998;39:514–519
  5. Look D , Locker D . Time saving in measurement of NMR and EPR relaxation times . Rev Sci Instruments . 1970;41:250–251
  6. Hänicke W , Merboldt KD , Chien D , et al.   Signal strength in subsecond FLASH magnetic resonance imaging (the dynamic approach to steady state) . Med Phys . 1990;17:1004–1010
  7. Cernicanu A, Axel L, Kim D. Self-calibrated rapid T1 measurements for quantitative perfusion studies. Proceedings of ISMRM 89th Scientific Assembly and Annual Meeting, Chicago, Nov. 30–Dec. 5, 2003. 1431 (oral presentation).
  8. Watson A , Rocklage S . Theory and mechanism of contrast-enhancing agents . In:  Higgins C ,  Hricak H ,  Helms C editor. Magnetic Resonance Imaging of the Body . New York: Raven; 1992;p. 1257–1287
  9. Gatehouse P , Ellington A , Ablitt N , et al.   Accurate assessment of the arterial input function during high-dose myocardial perfusion cardiovascular magnetic resonance . J Magn Reson Imaging . 2004;20:39–45
  10. Staewen RS , Johnson AJ , Ross BD , Parrish T , Merkle H , Garwood M . 3-D FLASH imaging using a single surface coil and a new adiabatic pulse, BIR-4 . Invest Radiol . 1990;25:559–567
  11. Garwood M , DelaBarre L . The return of the frequency sweep (designing adiabatic pulses for contemporary NMR) . J Magn Reson . 2001;153:155–177
  12. Kim D , Cernicanu A , Axel L . B(0) and B(1)-insensitive uniform T1-weighting for quantitative, first-pass myocardial perfusion magnetic resonance imaging . Magn Reson Med . 2005;54:1423–1429
  13. Cernicanu A, Kim D, Pai V, et al. Arterial Input Function Theoretical Calibration for First-Pass Quantitative Cardiac Perfusion Studies. Proceedings of ISMRM 13th Scientific Meeting and Exhibition, Miami, FL; 7–13 May, 2005; 113.
  14. Kim D , Axel L . Multi-slice, dual-imaging sequence for increasing the dynamic range of the contrast-enhanced blood signal and CNR of myocardial enhancement at 3T . J Magn Reson Imaging . 2005;23:81–86
  15. Zheng J , Venkatesan R , Haacke M , et al.   Accuracy of T1 measurements at high temporal resolution (feasibility of dynamic measurement of blood T1 after contrast administration) . J Magn Reson Imaging . 1999;10:576–581
  16. Ivancevic MK , Zimine I , Montet X , et al.   Inflow effect correction in fast gradient-echo perfusion imaging . Magn Reson Med . 2003;50:885–891
  17. Axel L, Kim D. In-Flow Effects in Determination of Arterial Input Functions. Proceedings ISMRM 14th Scientific Meeting and Exhibition, 6–12 May, 2006, Seattle, WA. In print.

 This work was supported by grant R01HL060009.

PII: S1076-6332(06)00130-9

doi: 10.1016/j.acra.2006.02.040

Academic Radiology
Volume 13, Issue 6 , Pages 686-693 , June 2006

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