Academic Radiology
Volume 15, Issue 1 , Pages 49-57 , January 2008

Optimization of Cardiac MSCT Contrast Injection Protocols: Dependency of the Main Bolus Contrast Density on Test Bolus Parameters and Patients’ Body Weight

  • Carsten Rist

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • Corresponding Author InformationAddress correspondence to: C.R.
    • ,
  • Christoph R. Becker

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Miles A. Kirchin

      Affiliations

    • Worldwide Medical Affairs, Bracco Imaging SpA, Milan, Italy
    • ,
  • Thorsten R. Johnson

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Stefanie Busch

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Kyongtae Ty Bae

      Affiliations

    • Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
    • ,
  • Alexander W. Leber

      Affiliations

    • Department of Cardiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Maximilian F. Reiser

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Konstantin Nikolaou

      Affiliations

    • Department of Clinical Radiology, University Hospitals – Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany

Received 4 June 2007 ,Accepted 3 August 2007.

References 

  1. Cademartiri F, van der Lugt A, Luccichenti G, et al. Parameters affecting bolus geometry in CTA: a review. J Comput Assist Tomogr. 2002;26:598–607
  2. Becker CR, Hong C, Knez A, et al. Optimal contrast application for cardiac 4-detector-row computed tomography. Invest Radiol. 2003;38:690–694
  3. Rist C, Nikolaou K, Kirchin MA, et al. Contrast bolus optimization for cardiac 16-slice computed tomography: comparison of contrast medium formulations containing 300 and 400 milligrams of iodine per milliliter. Invest Radiol. 2006;41:460–467
  4. Nikolaou K, Sagmeister S, Knez A, et al. Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes. Eur Radiol. 2003;13:2505–2512
  5. Schroeder S, Kopp AF, Baumbach A, et al. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol. 2001;37:1430–1435
  6. Cademartiri F, Nieman K, van der Lugt A, et al. Intravenous contrast material administration at 16-detector row helical CT coronary angiography: test bolus versus bolus-tracking technique. Radiology. 2004;233:817–823
  7. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT (Part I. Prediction with a computer model). Radiology. 1998;207:647–655
  8. Fleischmann D, Rubin GD, Bankier AA, et al. Improved uniformity of aortic enhancement with customized contrast medium injection protocols at CT angiography. Radiology. 2000;214:363–371
  9. Hittmair K, Wunderbaldinger P, Fleischmann D. [Contrast optimization in CT angiography]. Radiologe. 1999;39:93–99
  10. Hittmair K, Fleischmann D. Accuracy of predicting and controlling time-dependent aortic enhancement from a test bolus injection. J Comput Assist Tomogr. 2001;25:287–294
  11. Fleischmann D, Hittmair K. Mathematical analysis of arterial enhancement and optimization of bolus geometry for CT angiography using the discrete Fourier transform. J Comput Assist Tomogr. 1999;23:474–484
  12. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT (Part II. Effect of reduced cardiac output in a porcine model). Radiology. 1998;207:657–662
  13. Bae KT, Heiken JP, Brink JA. Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate—pharmacokinetic analysis and experimental porcine model. Radiology. 1998;206:455–464
  14. Wintersperger BJ, Nikolaou K, Jakobs TF, et al. Cardiac multidetector-row computed tomography: initial experience using 16 detector-row systems. Crit Rev Comput Tomogr. 2003;44:27–45
  15. Ludman PF, Coats AJ, Poole-Wilson PA, et al. Measurement accuracy of cardiac output in humans: indicator-dilution technique versus geometric analysis by ultrafast computed tomography. J Am Coll Cardiol. 1993;21:1482–1489
  16. Kaatee R, Van Leeuwen MS, De Lange EE, et al. Spiral CT angiography of the renal arteries: should a scan delay based on a test bolus injection or a fixed scan delay be used to obtain maximum enhancement of the vessels?. J Comput Assist Tomogr. 1998;22:541–547
  17. van Hoe L, Marchal G, Baert AL, et al. Determination of scan delay time in spiral CT-angiography: utility of a test bolus injection. J Comput Assist Tomogr. 1995;19:216–220
  18. Platt JF, Reige KA, Ellis JH. Aortic enhancement during abdominal CT angiography: correlation with test injections, flow rates, and patient demographics. AJR Am J Roentgenol. 1999;172:53–56
  19. Sheiman RG, Raptopoulos V, Caruso P, et al. Comparison of tailored and empiric scan delays for CT angiography of the abdomen. AJR Am J Roentgenol. 1996;167:725–729
  20. Cademartiri F, Mollet NR, Lemos PA, et al. Higher intracoronary attenuation improves diagnostic accuracy in MDCT coronary angiography. AJR Am J Roentgenol. 2006;187:W430–W433
  21. Nikolaou K, Becker CR, Muders M, et al. Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries. Atherosclerosis. 2004;174:243–252
  22. Johnson TR, Nikolaou K, Wintersperger BJ, et al. Dual-source CT cardiac imaging: initial experience. Eur Radiol. 2006;16:1409–1415
  23. Nikolaou K, Rist C, Wintersperger BJ, et al. Clinical value of MDCT in the diagnosis of coronary artery disease in patients with a low pretest likelihood of significant disease. AJR Am J Roentgenol. 2006;186(6):1659–1668
  24. Pugliese F, Mollet NR, Runza G, et al. Diagnostic accuracy of non-invasive 64-slice CT coronary angiography in patients with stable angina pectoris. Eur Radiol. 2006;16:575–582
  25. Mahnken AH, Muhlenbruch G, Gunther RW, et al. Cardiac CT: coronary arteries and beyond. Eur Radiol. 2007;17:994–1008
  26. Johnson TR, Nikolaou K, Wintersperger BJ, et al. Optimization of contrast material administration for electrocardiogram-gated computed tomographic angiography of the chest. J Comput Assist Tomogr. 2007;31:265–271
  27. Mahnken AH, Henzler D, Klotz E, et al. Determination of cardiac output with multislice spiral computed tomography: a validation study. Invest Radiol. 2004;39:451–454
  28. Bae KT, Tran HQ, Heiken JP. Multiphasic injection method for uniform prolonged vascular enhancement at CT angiography: pharmacokinetic analysis and experimental porcine model. Radiology. 2000;216:872–880
  29. Mahnken AH, Rauscher A, Klotz E, et al. Quantitative prediction of contrast enhancement from test bolus data in cardiac MSCT. Eur Radiol. 2007;17:1310–1319
  30. Cademartiri F, de Monye C, Pugliese F, et al. High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. Invest Radiol. 2006;41:349–353

PII: S1076-6332(07)00465-5

doi: 10.1016/j.acra.2007.08.005

Academic Radiology
Volume 15, Issue 1 , Pages 49-57 , January 2008

Article Tools

* Image Usage & Resolution