Academic Radiology
Volume 15, Issue 3 , Pages 342-349 , March 2008

Imaging Characteristics of DHOG, a Hepatobiliary Contrast Agent for Preclinical MicroCT in Mice

  • Tobias Henning

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • T.D.H. was supported by a stipend from the German Research Association (Deutsche Forschungsgemeinschaft).
    • Corresponding Author InformationAddress correspondence to: T.H.
    • ,
  • Axel W. Weber

      Affiliations

    • Department of Nuclear Medicine, München, Germany
    • ,
  • Jan S. Bauer

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • ,
  • Reinhard Meier

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • ,
  • Janette M. Carlsen

      Affiliations

    • Department of Nuclear Medicine, München, Germany
    • ,
  • Elizabeth J. Sutton

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • ,
  • Sven Prevrhal

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • ,
  • Sibylle I. Ziegler

      Affiliations

    • Department of Nuclear Medicine, München, Germany
    • ,
  • Hubertus Feussner

      Affiliations

    • Department of Surgery, München, Germany.
    • ,
  • Heike E. Daldrup-Link

      Affiliations

    • University of California San Francisco, 185 Berry St., Suite # 350, San Francisco, CA, 94107
    • ,
  • Ernst J. Rummeny

      Affiliations

    • Department of Radiology, München, Germany

Received 1 October 2007 ,Accepted 8 October 2007.

References 

  1. Weichert JP, Longino MA, Bakan DA, et al. Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver. J Med Chem. 1995;38:636–646
  2. Cooper AD. Hepatic uptake of chylomicron remnants. J Lipid Res. 1997;38:2173–2192
  3. Masuno H, Shiosaka T, Itoh Y, et al. Hepatic triglyceride lipase and lipoprotein lipase activities in post-heparin plasma of patients with various cancers. Jpn J Cancer Res. 1985;76:202–207
  4. Weichert JP, Longino MA, Spigarelli MG, et al. Computed tomography scanning of Morris hepatomas with liver-specific polyiodinated triglycerides. Acad Radiol. 1996;3:412–417
  5. Weichert JP, Lee FT, Longino MA, et al. Lipid-based blood-pool CT imaging of the liver. Acad Radiol. 1998;5(Suppl 1):S16S9; discussion S28–S30
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  7. Longino MA, Bakan DA, Weichert JP, et al. Formulation of polyiodinated triglyceride analogues in a chylomicron remnant-like liver-selective delivery vehicle. Pharm Res. 1996;13:875–879
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  12. Roberts TP. Physiologic measurements by contrast-enhanced MR imaging: expectations and limitations. J Magn Reson Imaging. 1997;7:82–90
  13. Bakan DA, Lee FT, Weichert JP, et al. Hepatobiliary imaging using a novel hepatocyte-selective CT contrast agent. Acad Radiol. 2002;9(Suppl 1):S194–S1949
  14. Violante MR, Dean PB, Fischer HW, et al. Particulate contrast media for computed tomographic scanning of the liver. Invest Radiol. 1980;15:S171–S175
  15. Cassel DM, Young SW, Brody WR, et al. Radiographic blood pool contrast agents for vascular and tumor imaging with projection radiography and computed tomography. J Comput Assist Tomogr. 1982;6:141–146
  16. Mattrey RF, Long DM, Peck WW, et al. Perfluoroctylbromide as a blood pool contrast agent for liver, spleen, and vascular imaging in computed tomography. J Comput Assist Tomogr. 1984;8:739–744
  17. Rummeny EJ, Berning W, Fuest M, et al. New RES-specific contrast agents for CT. Acad Radiol. 2002;9(Suppl 1):S185–S190
  18. Mukundan S, Ghaghada KB, Badea CT, et al. A liposomal nanoscale contrast agent for preclinical CT in mice. AJR Am J Roentgenol. 2006;186:300–307
  19. Vera DR, Mattrey RF. A molecular CT blood pool contrast agent. Acad Radiol. 2002;9:784–792
  20. Torchilin VP, Frank-Kamenetsky MD, Wolf GL. CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles. Acad Radiol. 1999;6:61–65

PII: S1076-6332(07)00572-7

doi: 10.1016/j.acra.2007.10.007

Academic Radiology
Volume 15, Issue 3 , Pages 342-349 , March 2008

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