Academic Radiology
Volume 15, Issue 5 , Pages 563-570 , May 2008

Pharmacokinetic Analysis of Malignant Pleural Mesothelioma—Initial Results of Tumor Microcirculation and its Correlation to Microvessel Density (CD-34)

  • Frederik L. Giesel, MD, MBA

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • Ohio State University, Columbus, OH.
    • Corresponding Author InformationAddress correspondence to: F.L.G.
    • ,
  • Peter L. Choyke, MD

      Affiliations

    • Molecular Imaging Program, NIH, Bethesda, MD
    • ,
  • Amit Mehndiratta, MBBS

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • School of Medical Science and Technology, IIT, Kharagpur, India
    • ,
  • Christian M. Zechmann, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Henrik von Tengg-Kobligk, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Klaus Kayser, MD

      Affiliations

    • UICC-TPCC, Institute of Pathology, Charite, Berlin, Germany
    • ,
  • Helge Bischoff, MD

      Affiliations

    • Radiotherapy and Biomedicine, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Christian Hintze, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Stefan Delorme, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • M.A. Weber, MD, MSc

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Marco Essig, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Hans-Ulrich Kauczor, MD

      Affiliations

    • Radiologie, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany
    • ,
  • Michael V. Knopp, MD, PhD

      Affiliations

    • Ohio State University, Columbus, OH.

Received 29 October 2007 ,Accepted 13 December 2007.

References 

  1. Kayser K, Becker C, Seeberg N, et al. Quantitation of asbestos and asbestos-like fibers in human lung tissue by hot and wet ashing, and the significance of their presence for survival of lung carcinoma and mesothelioma patients. Lung Cancer. 1999;24:89–98
  2. Kayser K, Bohm G, Blum S, et al. Glyco- and immunohistochemical refinement of the differential diagnosis between mesothelioma and metastatic carcinoma and survival analysis of patients. J Pathol. 2001;193:175–180
  3. Sugarbaker DJ, Flores RM, Jaklitsch MT, et al. Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg. 1999;117:54–63
  4. Choyke PL, Dwyer AJ, Knopp MV. Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging. 2003;17:509–520
  5. Knopp MV, Weiss E, Sinn HP, et al. Pathophysiologic basis of contrast enhancement in breast tumors. J Magn Reson Imaging. 1999;10:260–266
  6. Nosas-Garcia S, Moehler T, Wasser K, et al. Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma: a comparative study with histology and clinical markers. J Magn Reson Imaging. 2005;22:154–162
  7. Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol. 2006;24:3293–3298
  8. Hawighorst H, Knopp MV, Debus J, et al. Pharmacokinetic MRI for assessment of malignant glioma response to stereotactic radiotherapy: initial results. J Magn Reson Imaging. 1998;8:783–788
  9. Knopp MV, Tengg-Kobligk H, Choyke PL. Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring. Mol Cancer Ther. 2003;2:419–426
  10. Padhani AR, Gapinski CJ, Macvicar DA, et al. Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA. Clin Radiol. 2000;55:99–109
  11. Mayr NA, Hawighorst H, Yuh WT, et al. MR microcirculation assessment in cervical cancer: correlations with histomorphological tumor markers and clinical outcome. J Magn Reson Imaging. 1999;10:267–276
  12. Butchart EG, Ashcroft T, Barnsley WC, et al. Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura (Experience with 29 patients). Thorax. 1976;31:15–24
  13. Butchart EG. Surgery of mesothelioma of the pleura. In:  Roth JA,  Ruckdeschel JC,  Weinseinberger TH editor. Thoracic oncology. Philadelphia, PA: WB Saunders Co; 1989;p. 566–583
  14. Hoffmann U, Brix G, Knopp MV, et al. Pharmacokinetic mapping of the breast: a new method for dynamic MR mammography. Magn Reson Med. 1995;33:506–514
  15. Brix G, Semmler W, Port R, et al. Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr. 1991;15:621–628
  16. Kayser K, Trott J, Bohm G, et al. Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectors. Pathol Res Pract. 2005;201:791–801
  17. Kayser K, Gabius HJ. The application of thermodynamic principles to histochemical and morphometric tissue research: principles and practical outline with focus on the glycosciences. Cell Tissue Res. 1999;296:443–455
  18. Zou KH, Tuncali K, Silverman SG. Correlation and simple linear regression. Radiology. 2003;227:617–622
  19. Szoke T, Kayser K, Baumhakel JD, et al. Prognostic significance of microvascularization in cases of operated lung cancer. Eur J Cardiothorac Surg. 2005;27:1106–1111
  20. Kayser G, Baumhakel JD, Szoke T, et al. Vascular diffusion density and survival of patients with primary lung carcinomas. Virchows Arch. 2003;442:462–467
  21. Galbraith SM, Rustin GJ, Lodge MA, et al. Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging. J Clin Oncol. 2002;20:3826–3840
  22. Sorensen AG. Magnetic resonance as a cancer imaging biomarker. J Clin Oncol. 2006;24:3274–3281
  23. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182–1186
  24. Martincich L, Montemurro F, De Rosa G, et al. Monitoring response to primary chemotherapy in breast cancer using dynamic contrast-enhanced magnetic resonance imaging. Breast Cancer Res Treat. 2004;83:67–76
  25. Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1–8
  26. Mattern J, Koomagi R, Volm M. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. Br J Cancer. 1996;73:931–934
  27. Kumar-Singh S, Vermeulen PB, Weyler J, et al. Evaluation of tumour angiogenesis as a prognostic marker in malignant mesothelioma. J Pathol. 1997;182:211–216
  28. Ohta Y, Shridhar V, Bright RK, et al. VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours. Br J Cancer. 1999;81:54–61

PII: S1076-6332(07)00717-9

doi: 10.1016/j.acra.2007.12.014

Academic Radiology
Volume 15, Issue 5 , Pages 563-570 , May 2008

Article Tools

* Image Usage & Resolution