Functional MRI:1

Rationale and Objectives

To evaluate the functional alterations of chronic kidney disease (CKD) with magnetic resonance dynamic perfusion imaging.

Materials and methods

Twenty-one healthy subjects (42 kidneys) and 20 CKD patients (40 kidneys) underwent routine scans with fat-saturated T1-weighted fast low angle shot (FLASH) and true-fast imaging with steady-state precession (FISP) sequences followed by dynamic perfusion scans using a turbo-FLASH T1-weighted sequence. Signal intensity (SI) of the cortex and medulla on images was measured and plotted as a function of time. Peak height (P) and time to peak (T) of the cortex and medulla SI were estimated, and P/T ratio and the area under the time-intensity curves were calculated. We also tested the correlation between these data and serum creatinine (sCr) levels in patients.

Results

P, P/T ratio, and the area under the curve of patients' cortex and medulla were significantly decreased compared to control subjects, and T was delayed. In patients, P and P/T ratio of the cortex and P of the medulla were negatively correlated with sCr levels (r = −0.469, r = −0.419, and r = −0.423, respectively; P < 0.01).

Conclusion

Renal dysfunction in CKD can be evaluated by magnetic resonance dynamic perfusion imaging.

Key Words: Chronic kidney disease (CKD), magnetic resonance imaging (MRI), perfusion