Academic Radiology
Volume 16, Issue 1 , Pages 4-14 , January 2009

Conspicuity of Colorectal Polyps at CT Colonography: Visual Assessment, CAD Performance, and the Important Role of Polyp Height

  • Ronald M. Summers, MD, PhD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • Corresponding Author InformationAddress correspondence to: R.M.S.
    • ,
  • Suzanne M. Frentz, BS

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Jiamin Liu, PhD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Jianhua Yao, PhD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Linda Brown, MD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Adeline Louie, MD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Duncan S. Barlow, MD

      Affiliations

    • Colon Health Initiative, National Naval Medical Center, Bethesda, MD
    • ,
  • Donald W. Jensen, MD

      Affiliations

    • Colon Health Initiative, National Naval Medical Center, Bethesda, MD
    • ,
  • Andrew J. Dwyer, MD

      Affiliations

    • Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X, MSC 1182, Bethesda, MD 20892-1182
    • ,
  • Perry J. Pickhardt, MD

      Affiliations

    • Department of Radiology, University of Wisconsin School of Medicine, Madison, WI
    • ,
  • Nicholas Petrick, PhD

      Affiliations

    • LAMIS Image Analysis Laboratory, FDA/CDRH/OSEL, Silver Spring, MD

Received 8 April 2008 ,Accepted 9 June 2008.

References 

  1. Johnson CD, Toledano AY, Herman BA, et al. Computerized tomographic colonography: performance evaluation in a retrospective multicenter setting. Gastroenterology. 2003;125:688–695
  2. Petrick N, Haider M, Summers RM, et al. CT Colonography and computer-aided detection as a second reader: observer performance study. Radiology. 2008;246:148–156
  3. Kundel HL, Revesz G. Lesion conspicuity, structured noise, and film reader error. Am J Roentgenol. 1976;126:1233–1238
  4. Revesz G, Kundel HL, Graber MA. The influence of structured noise on the detection of radiologic abnormalities. Invest Radiol. 1974;9:479–486
  5. Revesz G, Kundel HL. Psycholophysical studies of detection errors in chest radiology. Radiology. 1977;123:559–562
  6. Krupinski EA, Berger WG, Dallas WJ, Roehrig H. Searching for nodules: what features attract attention and influence detection?. Acad Radiol. 2003;10:861–868
  7. Mulhall BP, Veerappan GR, Jackson JL. Meta-analysis: computed tomographic colonography. Ann Intern Med. 2005;142:635–650
  8. Shi R, Schraedley-Desmond P, Napel S, et al. CT colonography: influence of 3D viewing and polyp candidate features on interpretation with computer-aided detection. Radiology. 2006;239:768–776
  9. Summers RM, Yao J, Pickhardt PJ, et al. Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population. Gastroenterology. 2005;129:1832–1844
  10. Soetikno RM, Kaltenbach T, Rouse RV, et al. Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults. JAMA. 2008;299:1027–1035
  11. Pickhardt PJ, Choi JR, Hwang I, et al. Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med. 2003;349:2191–2200
  12. Pickhardt PJ, Choi JH. Electronic cleansing and stool tagging in CT colonography: advantages and pitfalls with primary three-dimensional evaluation. AJR Am J Roentgenol. 2003;181:799–805
  13. Altman DG. Practical statistics for medical research. Boca Raton, FL: Chapman & Hall/CRC; 1999;
  14. Park SH, Ha HK, Kim AY, et al. Flat polyps of the colon: detection with 16-MDCT colonography—preliminary results. AJR Am J Roentgenol. 2006;186:1611–1617
  15. Park SH, Ha HK, Kim MJ, et al. False-negative results at multi-detector row CT colonography: multivariate analysis of causes for missed lesions. Radiology. 2005;235:495–502
  16. Pickhardt PJ, Nugent PA, Choi JR, Schindler WR. Flat colorectal lesions in asymptomatic adults: implications for screening with CT virtual colonoscopy. AJR Am J Roentgenol. 2004;183:1343–1347
  17. Li J, Franaszek M, Petrick N, Yao J, Huang A, Summers RM. Wavelet method for CT colonography computer-aided polyp detection. In: 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, 2006; 2006:1316–1319.
  18. Li J, Van Uitert R, Yao J, et al. Wavelet method for CT colonography computer-aided polyp detection. Med Phys. 2008;35:3527–3538
  19. Pickhardt PJ, Choi JR, Nugent PA, Schindler WR. The effect of diagnostic confidence on the probability of optical colonoscopic confirmation of potential polyps detected on CT colonography: prospective assessment in 1,339 asymptomatic adults. AJR Am J Roentgenol. 2004;183:1661–1665
  20. Krupinski EA. Visual search of mammographic images: influence of lesion subtlety. Acad Radiol. 2005;12:965–969
  21. Kundel HL, Revesz G, Toto L. Contrast gradient and the detection of lung nodules. Invest Radiol. 1979;14:18–22
  22. Doshi T, Rusinak D, Halvorsen RA, Rockey DC, Suzuki K, Dachman AH. CT colonography: false-negative interpretations. Radiology. 2007;244:165–173
  23. Gluecker TM, Fletcher JG, Welch TJ, et al. Characterization of lesions missed on interpretation of CT colonography using a 2D search method. AJR Am J Roentgenol. 2004;182:881–889
  24. Arnesen RB, Adamsen S, Svendsen LB, Raaschou HO, von Benzon E, Hansen OH. Missed lesions and false-positive findings on computed-tomographic colonography: a controlled prospective analysis. Endoscopy. 2005;37:937–944
  25. Fidler JL, Fletcher JG, Johnson CD, et al. Understanding interpretive errors in radiologists learning computed tomography colonography. Acad Radiol. 2004;11:750–756

1 This research was supported in part by the Intramural Research Programs of the NIH Clinical Center and the National Institute of Biomedical Imaging and Bioengineering. No FDA endorsement of any product or company mentioned in this manuscript should be inferred. This work was presented at the 2007 RSNA Scientific Meeting, Chicago, IL.

PII: S1076-6332(08)00408-X

doi: 10.1016/j.acra.2008.06.007

Academic Radiology
Volume 16, Issue 1 , Pages 4-14 , January 2009

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