Academic Radiology
Volume 15, Issue 11 , Pages 1354-1359 , November 2008

Intracoronary Injection of Contrast Media Maps the Territory of the Coronary Artery: An MRI Technique for Assessing the Effects of Locally Delivered Angiogenic Therapies

Received 27 August 2008 ,Accepted 4 September 2008.

References 

  1. Yla-Herttuala S. An update on angiogenic gene therapy: vascular endothelial growth factor and other directions. Curr Opin Mol Ther. 2006;8:295–300
  2. Taylor DA, Atkins BZ, Hungspreugs P, et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med. 1998;4:929–933
  3. Zohlnhofer D, Ott I, Mehilli J, et al. Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA. 2006;295:1003–1010
  4. Fernandez-Aviles F, San Roman JA, Garcia-Frade J, et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res. 2004;95:742–748
  5. Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004;94:92–95
  6. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141–148
  7. Cleland JG, Freemantle N, Coletta AP, Clark AL. Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. Eur J Heart Fail. 2006;8:105–110
  8. Watzinger N, Saeed M, Wendland MF, Akbari H, Lund G, Higgins CB. Myocardial viability: magnetic resonance assessment of functional reserve and tissue characterization. J Cardiovasc Magn Reson. 2001;3:195–208
  9. Pearlman JD, Hibberd MG, Chuang ML, et al. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med. 1995;1:1085–1089
  10. Carlsson M, Osman NF, Ursell PC, Martin AJ, Saeed M. Quantitative MR measurements of regional and global left ventricular function and strain after intramyocardial transfer of VM202 into infarcted swine myocardium. Am J Physiol Heart Circ Physiol. 2008;295:H522–H532
  11. Saeed M, Saloner D, Martin A, et al. Adeno-associated viral vector-encoding vascular endothelial growth factor gene: effect on cardiovascular MR perfusion and infarct resorption measurements in swine. Radiology. 2007;243:451–460
  12. Kraitchman DL, Heldman AW, Atalar E, et al. In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation. 2003;107:2290–2293
  13. Serfaty JM, Atalar E, Declerck J, et al. Real-time projection MR angiography: feasibility study. Radiology. 2000;217:290–295
  14. Omary RA, Green JD, Schirf BE, Li Y, Finn JP, Li D. Real-time magnetic resonance imaging-guided coronary catheterization in swine. Circulation. 2003;107:2656–2659
  15. Saeed M, Martin AJ, Lee RJ, et al. MR guidance of targeted injections into border and core of scarred myocardium in pigs. Radiology. 2006;240:419–426
  16. Heiberg E, Engblom H, Engvall J, Hedstrom E, Ugander M, Arheden H. Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging. Scand Cardiovasc J. 2005;39:267–275
  17. Tsekos NV, Atalar E, Li D, Omary RA, Serfaty JM, Woodard PK. Magnetic resonance imaging-guided coronary interventions. J Magn Reson Imaging. 2004;19:734–749
  18. Saeed M, Henk CB, Weber O, et al. Delivery and assessment of endovascular stents to repair aortic coarctation using MR and x-ray imaging. J Magn Reson Imaging. 2006;24:371–378
  19. Saeed M, Saloner D, Weber O, Martin A, Henk C, Higgins C. MRI in guiding and assessing intramyocardial therapy. Eur Radiol. 2005;15:851–863
  20. Green JD, Omary RA, Schirf BE, et al. Comparison of x-ray fluoroscopy and interventional magnetic resonance imaging for the assessment of coronary artery stenoses in swine. Magn Reson Med. 2005;54:1094–1099

1 This study was supported by grant RO1HL07295 from the National Institutes of Health (Bethesda, MD) to Dr Saeed.

PII: S1076-6332(08)00503-5

doi: 10.1016/j.acra.2008.09.002

Academic Radiology
Volume 15, Issue 11 , Pages 1354-1359 , November 2008

Article Tools

* Image Usage & Resolution