Academic Radiology
Volume 16, Issue 2 , Pages 160-171 , February 2009

Dual-energy CT Discrimination of Iodine and Calcium: Experimental Results and Implications for Lower Extremity CT Angiography

  • David N. Tran, BS

      Affiliations

    • School of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room S-072, Stanford, CA 94305-5105
    • ,
  • Matus Straka, PhD

      Affiliations

    • Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, Room S-072, Stanford, CA 94305-5105
    • ,
  • Justus E. Roos, MD

      Affiliations

    • Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, Room S-072, Stanford, CA 94305-5105
    • ,
  • Sandy Napel, PhD

      Affiliations

    • Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, Room S-072, Stanford, CA 94305-5105
    • ,
  • Dominik Fleischmann, MD

      Affiliations

    • Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, Room S-072, Stanford, CA 94305-5105
    • Corresponding Author InformationAddress correspondence to: D.F.

Received 23 May 2008 ,Accepted 6 September 2008.

References 

  1. Kock MC, Adriaensen ME, Pattynama PM, et al. DSA versus multi-detector row CT angiography in peripheral arterial disease: randomized controlled trial. Radiology. 2005;237:727–737
  2. Ouwendijk R, de Vries M, Pattynama PM, et al. Imaging peripheral arterial disease: a randomized controlled trial comparing contrast-enhanced MR angiography and multi-detector row CT angiography. Radiology. 2005;236:1094–1103
  3. Fleischmann D, Hallett RL, Rubin GD. CT angiography of peripheral arterial disease. J Vasc Interv Radiol. 2006;17:3–26
  4. Rubin GD, Schmidt AJ, Logan LJ, Sofilos MC. Multi-detector row CT angiography of lower extremity arterial inflow and runoff: initial experience. Radiology. 2001;221:146–158
  5. Ouwendijk R, Kock MC, van Dijk LC, van Sambeek MR, Stijnen T, Hunink MG. Vessel wall calcifications at multi-detector row CT angiography in patients with peripheral arterial disease: effect on clinical utility and clinical predictors. Radiology. 2006;241:603–608
  6. Roos JE, Fleischmann D, Koechl A, et al. Multipath curved planar reformation of the peripheral arterial tree in CT angiography. Radiology. 2007;244:281–290
  7. Chiro GD, Brooks RA, Kessler RM, et al. Tissue signatures with dual-energy computed tomography. Radiology. 1979;131:521–523
  8. Millner MR, McDavid WD, Waggener RG, Dennis MJ, Payne WH, Sank VJ. Extraction of information from CT scans at different energies. Med Phys. 1979;6:70–71
  9. Kelcz F, Joseph P, Hilal S. Noise considerations in dual energy CT scanning. Med Phys. 1979;6:418–425
  10. Flohr TG, McCollough CH, Bruder H, et al. First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol. 2006;16:256
  11. Carmi R, Naveh G, Altman A. Material separation with dual-layer CT. In: Nuclear science symposium conference record. San Juan, PR: IEEE Nuclear and Plasma Sciences Society; 2005;p. 1876–1878
  12. Kuribayashi S. Dual energy CT of peripheral arterial disease with single-source 64-slice MDCT. Presented at: 9th Annual International Symposium on MDCT; San Francisco, CA 2007;
  13. Alvarez RE, Macovski A. Energy-selective reconstructions in x-ray computerized tomography. Phys Med Biol. 1976;21:733–744
  14. Boll DT, Hoffmann MH, Huber N, Bossert AS, Aschoff AJ, Fleiter TR. Spectral coronary multidetector computed tomography angiography: dual benefit by facilitating plaque characterization and enhancing lumen depiction. J Comput Assist Tomogr. 2006;30:804–811
  15. Johnson T, Krauss B, Sedlmair M, et al. Material differentiation by dual energy CT: initial experience. Eur Radiol. 2007;17:1510–1517
  16. Kanitsar A, Wegenkittl R, Felkel P, Fleischmann D, Sandner D, Groeller E. Computed tomography angiography: a case study of peripheral vessel investigation. In: Proceedings of IEEE visualization. San Diego, CA: IEEE Computer Society; 2001;p. 477–480
  17. Langheinrich AC, Bohle RM, Greschus S, et al. atherosclerotic lesions at micro CT: feasibility for analysis of coronary artery wall in autopsy specimens. Radiology. 2004;231:675–681
  18. Ota H, Takase K, Igarashi K, et al. MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: importance of reviewing cross-sectional images. AJR Am J Roentgenol. 2004;182:201–209
  19. Hubbell JH, Seltzer SM. Tables of x-ray mass attenuation coefficients and mass energy-absorption coefficients (version 1.4). Gaithersburg, MD: National Institute of Standards and Technology; 2004;
  20. Lehmann LA, Alvarez RE, Macovski A, et al. Generalized image combinations in dual KVP digital radiography. Med Phys. 1981;8:659–667
  21. Lawson CL, Hanson RJ. Solving least squares problems. Englewood Cliffs, NJ: Prentice Hall; 1974;

1 This work was supported in part by grant 1R01HL67194 from the National Institutes of Health (Bethesda, MD), an In-Training Award from the Society of Computed Body Tomography & Magnetic Resonance (Reston, VA), a Seed Grant from the American Medical Association (Chicago, IL), and the Stanford University Medical Research Scholars Program (Stanford, CA).

PII: S1076-6332(08)00535-7

doi: 10.1016/j.acra.2008.09.004

Academic Radiology
Volume 16, Issue 2 , Pages 160-171 , February 2009

Article Tools

* Image Usage & Resolution