Academic Radiology
Volume 16, Issue 10 , Pages 1187-1195 , October 2009

Quantitative Assessment of Blood Volume and Permeability in Cerebral Mass Lesions using Dynamic Contrast-Enhanced Computed Tomography in the Dog

  • Alexander G. MacLeod, DVM

      Affiliations

    • Veterinary Medical Teaching Hospital, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616
    • ,
  • Peter J. Dickinson, BVSc, PhD

      Affiliations

    • Department of Surgical and Radiological Sciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616
    • ,
  • Richard A. LeCouteur, BVSc, PhD

      Affiliations

    • Department of Surgical and Radiological Sciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616
    • ,
  • Robert J. Higgins, BVSc, PhD

      Affiliations

    • Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616
    • ,
  • Rachel E. Pollard, DVM, PhD

      Affiliations

    • Department of Surgical and Radiological Sciences, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616
    • Corresponding Author InformationAddress correspondence to: R.E.P.

Received 5 February 2009 ,Revised 16 March 2009 ,Accepted 18 March 2009.

References 

  1. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst. 1990;82:4–6
  2. Lebelt A, Dzieciol J, Guzinska-Ustymowicz K, et al. Angiogenesis in gliomas. Folia Histochem Cytobiol. 2008;46:69–72
  3. Rosen LS. Clinical experience with angiogenesis signaling inhibitors: focus on vascular endothelial growth factor (VEGF) blockers. Cancer Control. 2002;9(2 Suppl):36–44
  4. Aronen HJ, Gazit IE, Louis DN, et al. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology. 1994;191:41–51
  5. Guha A, Mukherjee J. Advances in the biology of astrocytomas. Curr Opin Neurol. 2004;17:655–662
  6. Angelov L, Salhia B, Roncari L, et al. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Cancer Res. 1999;59:5536–5541
  7. Atiqur Rahman M, Toi M. Anti-angiogenic therapy in breast cancer. Biomed Pharmacother. 2003;57:463–470
  8. Capdeville R, Buchdunger E, Zimmermann J, et al. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov. 2002;1:493–502
  9. Katayama R, Huelsmeyer MK, Marr AK, et al. Imatinib mesylate inhibits platelet-derived growth factor activity and increases chemosensitivity in feline vaccine-associated sarcoma. Cancer Chemother Pharmacol. 2004;54:25–33
  10. Wong ET, Brem S. Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities. J Natl Compr Canc Netw. 2008;6:515–522
  11. Blomley MJ, Coulden R, Bufkin C, et al. Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion. Invest Radiol. 1993;28(Suppl 5):S72–S77discussion S78
  12. Cenic A, Nabavi DG, Craen RA, et al. Dynamic CT measurement of cerebral blood flow: a validation study. AJNR Am J Neuroradiol. 1999;20:63–73
  13. Brasch RC, Gossmann A, Helbich TH, et al. Can a small-molecular gadolinium contrast agent be applied successfully with dynamic MRI to quantitatively define brain tumor microvascular responses to angiogenesis inhibition?. Acad Radiol. 2002;2)(9(Suppl):S326–S327
  14. Haroon HA, Patankar TF, Zhu XP, et al. Comparison of cerebral blood volume maps generated from T2∗ and T1 weighted MRI data in intra-axial cerebral tumours. Br J Radiol. 2007;80:161–168
  15. Evelhoch JL. Key factors in the acquisition of contrast kinetic data for oncology. J Magn Reson Imaging. 1999;10:254–259
  16. Ding B, Ling HW, Chen KM, et al. Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging. Neuroradiology. 2006;48:773–781
  17. Eastwood JD, Lev MH, Azhari T, et al. CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke. Radiology. 2002;222:227–236
  18. Miles KA. Tumour angiogenesis and its relation to contrast enhancement on computed tomography: a review. Eur J Radiol. 1999;30:198–205
  19. Roberts HC, Roberts TP, Lee TY, et al. Dynamic contrast-enhanced computed tomography (CT) for quantitative estimation of microvascular permeability in human brain tumors. Acad Radiol. 2002;2)(9(Suppl):S364–S367
  20. Cenic A, Nabavi DG, Craen RA, et al. A CT method to measure hemodynamics in brain tumors: validation and application of cerebral blood flow maps. AJNR Am J Neuroradiol. 2000;21:462–470
  21. Candolfi M, Curtin JF, Nichols WS, et al. Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. J Neurooncol. 2007;85:133–148
  22. Lipsitz D, Higgins RJ, Kortz GD, et al. Glioblastoma multiforme: clinical findings, magnetic resonance imaging, and pathology in five dogs. Vet Pathol. 2003;40:659–669
  23. Dickinson PJ, Sturges BK, Higgins RJ, et al. Vascular endothelial growth factor mRNA expression and peritumoral edema in canine primary central nervous system tumors. Vet Pathol. 2008;45:131–139
  24. Rossmeisl JH, Duncan RB, Huckle WR, et al. Expression of vascular endothelial growth factor in tumors and plasma from dogs with primary intracranial neoplasms. Am J Vet Res. 2007;68:1239–1245
  25. Peterson KL, MacLeod AG, Wisner ER, et al. Quantitative assessment of blood volume, blood flow, and permeability of the brain of clinically normal dogs by use of dynamic contrast-enhanced computed tomography. Am J Vet Res. 2008;69:45–50
  26. Kishimoto M, Yamada K, Seok JS, et al. Analysis of blood flow in a third ventricular ependymoma and an olfactory bulb meningioma by using perfusion computed tomography. J Vet Med Sci. 2008;70:981–983
  27. Koblik PD, LeCouteur RA, Higgins RJ, et al. CT-guided brain biopsy using a modified Pelorus Mark III stereotactic system: experience with 50 dogs. Vet Radiol Ultrasound. 1999;40:434–440
  28. Koblik PD, LeCouteur RA, Higgins RJ, et al. Modification and application of a Pelorus Mark III stereotactic system for CT-guided brain biopsy in 50 dogs. Vet Radiol Ultrasound. 1999;40:424–433
  29. Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 2002;61:215–225discussion 226–229
  30. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97–109
  31. Barresi V, Cerasoli S, Vitarelli E, et al. Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas. Acta Neuropathol. 2007;114:147–156
  32. Dennis Cheong LH, Tchoyoson Lim CC, Koh TS. Dynamic contrast-enhanced CT of intracranial meningioma: comparison of distributed and compartmental tracer kinetic models—initial results. Radiology. 2004;232:921–930
  33. Haris M, Gupta RK, Singh A, et al. Differentiation of infective from neoplastic brain lesions by dynamic contrast-enhanced MRI. Neuroradiology. 2008;50:531–540
  34. Maia AC, Malheiros SM, da Rocha AJ, et al. MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas. AJNR Am J Neuroradiol. 2005;26:777–783
  35. Nabavi DG, Cenic A, Henderson S, et al. Perfusion mapping using computed tomography allows accurate prediction of cerebral infarction in experimental brain ischemia. Stroke. 2001;32:175–183
  36. Hellier KD, Hampton JL, Guadagno JV, et al. Perfusion CT helps decision making for thrombolysis when there is no clear time of onset. J Neurol Neurosurg Psychiatry. 2006;77:417–419

 Presented in part at the Annual American College of Veterinary Medicine Meeting, Vancouver, British Columbia, August 2006.

PII: S1076-6332(09)00250-5

doi: 10.1016/j.acra.2009.03.015

Academic Radiology
Volume 16, Issue 10 , Pages 1187-1195 , October 2009

Article Tools

* Image Usage & Resolution