Academic Radiology
Volume 17, Issue 1 , Pages 48-53 , January 2010

Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study

  • George R. Washko, MD

      Affiliations

    • Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston MA
    • ,
  • David A. Lynch, MD

      Affiliations

    • Department of Radiology, National Jewish Medical and Research Center, Denver CO
    • ,
  • Shin Matsuoka, MD

      Affiliations

    • Department of Radiology, Brigham and Women's Hospital, Boston MA
    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston MA
    • ,
  • James C. Ross, MS

      Affiliations

    • Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
    • ,
  • Shigeaki Umeoka, MD, PhD

      Affiliations

    • Department of Radiology, Brigham and Women's Hospital, Boston MA
    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston MA
    • ,
  • Alejandro Diaz, MD

      Affiliations

    • Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
    • ,
  • Frank C. Sciurba, MD

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Gary M. Hunninghake, MD

      Affiliations

    • Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
    • Channing Laboratory, Brigham and Women's Hospital, Boston MA
    • ,
  • Raúl San José Estépar, PhD

      Affiliations

    • Department of Radiology, National Jewish Medical and Research Center, Denver CO
    • ,
  • Edwin K. Silverman, MD, PhD

      Affiliations

    • Channing Laboratory, Brigham and Women's Hospital, Boston MA
    • ,
  • Ivan O. Rosas, MD

      Affiliations

    • Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
    • Department of Radiology, Brigham and Women's Hospital, Boston MA
    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston MA
    • Corresponding Author InformationAddress correspondence to: I.O.R.
    • ,
  • Hiroto Hatabu, MD, PhD

      Affiliations

    • Department of Radiology, Brigham and Women's Hospital, Boston MA
    • Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston MA
    • Corresponding Author InformationAddress correspondence to: H.H.

Received 30 June 2009 ,Accepted 19 July 2009.

References 

  1. King TEJ, Tooze JA, Schwarz MI, et al. Predicting survival in idiopathic pulmonary fibrosis. scoring system and survival model. Am J Respir Crit Care Med. 2001;164:1171–1181
  2. Raghu G, Weycker D, Edelsberg J, et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174:810–816
  3. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med. 2001;345:517–525
  4. Demedts M, Behr J, Buhl R, et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 2005;353:2229–2242
  5. King TE, Behr J, Brown KK, et al. BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2008;177:75–81
  6. Rosas IO, Ren P, Avila NA, et al. Early interstitial lung disease in familial pulmonary fibrosis. Am J Respir Crit Care Med. 2007;176:698–705
  7. Lynch DA, Sahin H, Garg K. Prevalence of infiltrative lung disease identified on ct in participants in the national lung screening trial. Abstract RSNA. 2008;SSQ04–04:609
  8. Fisher RA. On the interpretation of X2 from contingency tables, and the calculation of P. J R Stat Soc. 1922;85:87094
  9. Wilcoxon F. Individual comparisons by ranking methods. Biometrics. 1945;1:80–83
  10. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532–555
  11. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  12. Attili AK, Kazerooni EA, Gross BH, et al. Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 2008;28:1383–1396
  13. Gochuico BR, Avila NA, Chow CK, et al. Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Intern Med. 2008;168:159–166
  14. Caminati A, Harari S. Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis. Proc Am Thorac Soc. 2006;3:299–306
  15. Baumgartner KB, Samet JM, Stidley CA, et al. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1997;155:242–248
  16. Flaherty KR, Hunninghake GG. Smoking: an injury with many lung manifestations. Am J Respir Crit Care Med. 2005;172:1070–1071
  17. Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 2001;134:136–151
  18. Baran CP, Opalek JM, McMaken S, et al. Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2007;176:78–89
  19. Nogee LM, Dunbar AE, Wert SE, et al. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med. 2001;344:573–579
  20. Hodgson U, Laitinen T, Tukiainen P. Nationwide prevalence of sporadic and familial idiopathic pulmonary fibrosis: evidence of founder effect among multiplex families in Finland. Thorax. 2002;57:338–342
  21. Steele MP, Speer MC, Loyd JE, et al. Clinical and pathologic features of familial interstitial pneumonia. Am J Respir Crit Care Med. 2005;172:1146–1152
  22. Marshall RP, Puddicombe A, Cookson WO, et al. Adult familial cryptogenic fibrosing alveolitis in the United Kingdom. Thorax. 2000;55:143–146
  23. Bitterman PB, Rennard SI, Keogh BA, et al. Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. N Engl J Med. 1986;314:1343–1347
  24. Tsakiri KD, Cronkhite JT, Kuan PJ, et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A. 2007;104:7552–7557
  25. Armanios MY, Chen JJL, Cogan JD, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356:1317–1326

 COPDGene is supported by grants U01 HL089897 and U01 HL089856 from the National Institutes of Health (NIH; Bethesda, MD). Dr Washko is supported by grant K23 HL089353 from the NIH and an award from the Parker B. Francis Foundation (Kansas City, MO). Dr Hunninghake is supported by grant K08 HL092222 from the NIH. Dr Rosas is supported by grant HL087030 from the NIH. Dr Hatabu is supported by grant 5R21CA116271-2 from the NIH

PII: S1076-6332(09)00414-0

doi: 10.1016/j.acra.2009.07.016

Academic Radiology
Volume 17, Issue 1 , Pages 48-53 , January 2010

Article Tools

* Image Usage & Resolution