Academic Radiology
Volume 17, Issue 1 , Pages 54-60 , January 2010

Long Residence Time of Ultrasound Microbubbles Targeted to Integrin in Murine Tumor Model

  • Hong Young Jun

      Affiliations

    • Department of Radiology and the Institute for Radiological Imaging Science, Wonkwang University, 344-2 Sinyong Dong, Iksan, Jeonbuk 570-711, South Korea
  • ,
  • Seong Hoon Park, MD

      Affiliations

    • Department of Radiology and the Institute for Radiological Imaging Science, Wonkwang University, 344-2 Sinyong Dong, Iksan, Jeonbuk 570-711, South Korea
  • ,
  • Hun Soo Kim, MD

      Affiliations

    • Department of Pathology, Wonkwang University, 344-2 Sinyong Dong, Iksan, Jeonbuk 570-711, South Korea
  • ,
  • Kwon-Ha Yoon, MD, PhD

      Affiliations

    • Department of Radiology and the Institute for Radiological Imaging Science, Wonkwang University, 344-2 Sinyong Dong, Iksan, Jeonbuk 570-711, South Korea
    • Corresponding Author InformationAddress correspondence to: K.-H.Y.

Received 15 May 2009 ,Accepted 19 July 2009.

References 

  1. Kono Y, Steinbach GC, Peterson T, et al. Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats. Radiology. 2002;224:253–257
  2. Leong-Poi H, Christiansen J, Klibanov AL, et al. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003;107:455–460
  3. Lum AF, Borden MA, Dayton PA, et al. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release. 2006;111:128–134
  4. Klibanov AL. Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol. 2006;41:354–362
  5. Borden MA, Caskey CF, Little E, et al. DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir. 2007;23:9401–9408
  6. Leong-Poi H, Kuliszewski MA, Lekas M, et al. Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res. 2007;101:295–303
  7. Suzuki R, Takizawa T, Negishi Y, et al. Effective gene delivery with liposomal bubbles and ultrasound as novel non-viral system. J Drug Target. 2007;15:531–537
  8. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569–571
  9. Sipkins DA, Cheresh DA, Kazemi MR, et al. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998;4:623–626
  10. Gasparini G, Brooks PC, Biganzoli E, et al. Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res. 1998;4:2625–2634
  11. Weller GE, Wong MK, Modzelewski RA, et al. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res. 2005;65:533–539
  12. Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation. 2003;108:336–341
  13. Hasik MJ, Kim DH, Howle LE, et al. Evaluation of synthetic phospholipid ultrasound contrast agents. Ultrasonics. 2002;40:973–982
  14. Haubner R, Wester HJ, Reuning U, et al. Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med. 1999;40:1061–1071
  15. Thumshirn G, Hersel U, Goodman SL, et al. Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation. Chemistry. 2003;9:2717–2725
  16. Klibanov AL. Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconj Chem. 2005;16:9–17
  17. Joseph S, Olbrich C, Kirsch J, et al. A real-time in vitro assay for studying functional characteristics of target-specific ultrasound contrast agents. Pharm Res. 2004;21:920–926
  18. Choi KS, Kim SH, Cai QY, et al. Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Mol Imaging. 2007;6:75–84
  19. Klibanov AL, Rychak JJ, Yang WC, et al. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast Media Mol Imaging. 2006;1:259–266
  20. Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. 2007;9:415–447
  21. Lindner JR, Song J, Christiansen J, et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001;104:2107–2112
  22. Janssen ML, Oyen WJ, Dijkgraaf I, et al. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 2002;62:6146–6151

PII: S1076-6332(09)00415-2

doi: 10.1016/j.acra.2009.07.017

Academic Radiology
Volume 17, Issue 1 , Pages 54-60 , January 2010