Academic Radiology
Volume 16, Issue 12 , Pages 1475-1482 , December 2009

Longitudinal Assessment of Colonic Tumor Fate in Mice by Computed Tomography and Optical Colonoscopy

  • Benjamin Y. Durkee, PhD

      Affiliations

    • Department of Medical Physics, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • ,
  • Kazuhiko Shinki, PhD

      Affiliations

    • Department of Radiology, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • ,
  • Michael A. Newton, PhD

      Affiliations

    • Department of Biostatistics and Medical Informatics and Department of Statistics, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • ,
  • Caitlin E. Iverson, BS

      Affiliations

    • McArdle Laboratory for Cancer Research – Department of Oncology, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • ,
  • Jamey P. Weichert, PhD

      Affiliations

    • Department of Medical Physics, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • Department of Radiology, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • ,
  • William F. Dove, PhD

      Affiliations

    • McArdle Laboratory for Cancer Research – Department of Oncology, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • Laboratory of Genetics, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • Corresponding Author InformationAddress correspondence to: W.F.D.
    • ,
  • Richard B. Halberg, PhD

      Affiliations

    • McArdle Laboratory for Cancer Research – Department of Oncology, University of Wisconsin – Madison, 1400 University Avenue, Madison, WI 53706
    • Corresponding Author InformationAddress correspondence to: R.B.H.

Received 7 May 2009 ,Accepted 23 July 2009.

References 

  1. Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science. 1990;247:322–324
  2. Shoemaker AR, Gould KA, Luongo C, et al. Studies of neoplasia in the Min mouse. Biochim Biophys Acta. 1997;1332:F25–F48
  3. Corpet DE, Pierre F. Point: from animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev. 2003;12:391–400
  4. Jacoby RF, Cole CE, Tutsch K, et al. Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. Cancer Res. 2000;60:1864–1870
  5. Ritland SR, Gendler SJ. Chemoprevention of intestinal adenomas in the ApcMin mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression. Carcinogenesis. 1999;20:51–58
  6. Jacoby RF, Marshall DJ, Newton MA, et al. Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam. Cancer Res. 1996;56:710–714
  7. Jacoby RF, Seibert K, Cole CE, et al. The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the Min mouse model of adenomatous polyposis. Cancer Res. 2000;60:5040–5044
  8. Bruce WR. Counterpoint: from animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies. Cancer Epidemiol Biomarkers Prev. 2003;12:401–404
  9. Hensley HH, Chang WC, Clapper ML. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn Reson Med. 2004;52:524–529
  10. Hensley HH, Merkel CE, Chang WC, et al. Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse. Gastrointest Endosc. 2009;69:742–749
  11. Pickhardt PJ, Halberg RB, Taylor AJ, et al. Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model. Proc Natl Acad Sci U S A. 2005;102:3419–3422
  12. Becker C, Fantini MC, Neurath MF. High resolution colonoscopy in live mice. Nature Protocols. 2006;1:2900–3904
  13. Durkee BY, Mudd SR, Roen CN, et al. Reproducibility of tumor volume measurement at microCT colonography in living mice. Acad Radiol. 2008;15:334–341
  14. Becker C, Fantini MC, Wirtz S, et al. In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut. 2005;54:950–954
  15. Cooper HS, Everley L, Chang WC, et al. The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis. Gastroenterology. 2001;121:1407–1416
  16. Akaike H. New look at statistical-model identification. IEEE Trans Automatic Control. 1974;AC19:716–723
  17. Efron B, Tibshirani RJ. An introduction to the bootstrap. Boca Raton, FL: Chapman & Hall/CRC; 1993;
  18. Ware JH. Linear models for the analysis of longitudinal studies. Am Statistician. 1985;39:95–101
  19. Kim DH, Pickhardt PJ, Taylor AJ, et al. CT colonography versus colonoscopy for the detection of advanced neoplasia. N Engl J Med. 2007;357:1403–1412
  20. Jackson-Thompson J, Ahmed F, German RR, et al. Descriptive epidemiology of colorectal cancer in the United States, 1998–2001. Cancer. 2006;107:1103–1111
  21. Regula J, Rupinski M, Kraszewska E, et al. Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med. 2006;355:1863–1872
  22. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321–333
  23. Amos-Landgraf JM, Kwong LN, Kendziorski CM, et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A. 2007;104:4036–4041
  24. Thirion P, Michiels S, Pignon JP, et al. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J Clin Oncol. 2004;22:3766–3775
  25. Blijham GH. Chemotherapy of colorectal cancer. Anticancer Drugs. 1991;2:233–245
  26. Tucker JM, Davis C, Kitchens ME, et al. Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in ApcMin/+ mice. Cancer Lett. 2002;187:153–162
  27. Uronis JM, Herfarth HH, Rubinas TC, et al. Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage. Cancer Res. 2007;67:11594–11600
  28. Gambino JJ, Lindberg RG. Response of the pocket mouse to ionizing radiation. Radiat Res. 1964;22:586–597
  29. Halberg RB, Waggoner J, Rasmussen K. Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Research. 2009;69:5768–5775

 Supported by funds to Jamey Weichert from the University of Wisconsin Comprehensive Cancer Center, grants R37CA63677and U01CA84227 to William F. Dove from the National Cancer Institute, grant R01 CA64364 to Michael A. Newton from the National Cancer Institute, and grant U19CA113297–03 to Ben Shen from the National Cancer Institute NCDDG Program.

PII: S1076-6332(09)00427-9

doi: 10.1016/j.acra.2009.07.023

Academic Radiology
Volume 16, Issue 12 , Pages 1475-1482 , December 2009

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