Academic Radiology
Volume 17, Issue 1 , Pages 7-17 , January 2010

Detecting Epidermal Growth Factor Receptor Tumor Activity In Vivo During Cetuximab Therapy of Murine Gliomas

  • Summer L. Gibbs-Strauss, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL-B05, Boston, MA 02215
    • Corresponding Author InformationAddress correspondence to: S.L.G.-S.
    • ,
  • Kimberley S. Samkoe, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • ,
  • Julia A. O'Hara, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • ,
  • Scott C. Davis, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • ,
  • P. Jack Hoopes, DVM, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • Department of Surgery, Dartmouth College, Hanover NH
    • ,
  • Tayyaba Hasan, PhD

      Affiliations

    • Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA 02115
    • ,
  • Brian W. Pogue, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, Hanover NH
    • Department of Surgery, Dartmouth College, Hanover NH
    • Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA

Received 6 April 2009 ,Accepted 24 July 2009.

References 

  1. Sathornsumetee S, Rich JN. New treatment strategies for malignant glioma. Exp Rev Anticancer Ther. 2006;6:1087–1104
  2. Sathornsumetee S, Reardon DA, Desjardins A, et al. Molecularly targeted therapy for malignant glioma. Cancer. 2007;110:13–24
  3. Mischel PS, Cloughesy TF. Targeted molecular therapy of GBM. Brian Pathol. 2003;13:52–61
  4. Krishnan S, Rao RD, James CD, et al. Combination of epidermal growth factor targeted therapy with radiation therapy for malignant glioma. Front Biosci. 2003;8:e1–e13
  5. Halatsch ME, Schmidt U, Behnke-Mursch J, et al. Epidermal growth factor receptor inhibitors for the treatment of glioblastoma multiforme and other malignant brain tumors. Cancer Treat Rev. 2006;32:74–89
  6. Marshall J. Clinical implications of the mechanism of epidermal growth factor receptor inhibitors. Cancer. 2006;107:1207–1218
  7. Harding J, Burtness B. Cetuximab: an epidermal growth factor receptor chimeric human-murine monoclonal antibody. Drugs Today. 2005;41:107–127
  8. Eller JL, Longo SL, Hicklin DJ, et al. Activity of anti-epidermal growth factor receptor monocolonal antibody C225 against glioblastoma multiforme. Neurosurgery. 2002;51:1005–1014
  9. Eller JL, Longo SL, Kyle MM, et al. Anti-epidermal growth factor receptor monocolonal antibody cetuximab augments radiation effects in glioblastoma multiforme in vitro and in vivo. Neurosurgery. 2005;56:155–162
  10. Sokolov K, Nida D, Descour M, et al. Molecular optical imaging of therapeutic targets of cancer. Adv Cancer Res. 2007;96:299–344
  11. Moore A, Marecos E, Simonova M, et al. Novel gliosarcoma cell line expressing green fluorescent protein: a model for quantitative assessment of angiogenesis. Microvasc Res. 1998;56:145–153
  12. Davis SC, Pogue BW, Springett R, et al. Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue. Rev Sci Instrum. 2008;79;064302
  13. Ntziachristos V, Turner G, Dunham J, et al. Planar fluorescence imaging using normalized data. J Biomed Optics. 2005;10:064007-1–064007-18
  14. Raben D, Helfrich B, Chan DC, et al. The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer. Clin Cancer Res. 2005;11:795–805
  15. Luo FR, Yang Z, Dong H, et al. Correlation of pharmacokinetics with the antitumor activity of cetuximab in nude mice bearing the GEO human colon carcinoma xenograft. Cancer Chemother Pharmacol. 2005;56:455–464
  16. Gauthier-Balin D, Delord JP, Rochaix P, et al. In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different levels of EGFR. Cancer Chemother Pharmacol. 2006;57:709–718
  17. Kovar JL, Johnson MA, Volcheck WM, et al. Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model. Am J Pathol. 2006;169:1415–1426
  18. Pogue BW, Davis SC, Song X, et al. Image analysis methods for diffuse optical tomography. J Biomed Optics. 2006;11:033001-1–033001-16
  19. Kim ES, Khuri FR, Herbst RS. Epidermal growth factor receptor biology (IMC-C225). Curr Opin Oncol. 2001;13:506–513
  20. Baselga J. The EGFR as a target for anticancer therapy—focus on cetuximab. Eur J Cancer. 2001;37:S16–S22

 This work was funded by grants RO1CA109558 and PO1CA84203 from the National Cancer Institute (Bethesda, MD) as well as the Norris Cotton Cancer Center Shared Resources (Lebanon, NH).

PII: S1076-6332(09)00431-0

doi: 10.1016/j.acra.2009.07.027

Academic Radiology
Volume 17, Issue 1 , Pages 7-17 , January 2010

Article Tools

* Image Usage & Resolution