Academic Radiology
Volume 17, Issue 1 , Pages 75-83 , January 2010

HRCT Features of Small Peripheral Lung Carcinomas Detected in a Low-dose CT Screening Program

  • Shusuke Sone, MD

      Affiliations

    • JA Nagano Azumi General Hospital, Ikeda, Nagano, Japan (present affiliation: Nagano Health Promotion Corporation, Inasato, Nagano 381-2298, Japan)
    • Corresponding Author InformationAddress correspondence to: S.S.
  • ,
  • Toru Matsumoto, BS, PhD

      Affiliations

    • National Institute of Radiological Sciences, Inage, Chiba, Japan
  • ,
  • Takayuki Honda, MD

      Affiliations

    • Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan
  • ,
  • Kenji Tsushima, MD

      Affiliations

    • Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
  • ,
  • Fumiyoshi Takayama, MD

      Affiliations

    • Department of Radiology, JA Nagano Azumi General Hospital, Ikeda, Nagano, Japan (present affiliation: Ichinose Neurosurgery Hospital, Matsumoto, Nagano, Japan)
  • ,
  • Takaomi Hanaoka, MD

      Affiliations

    • Department of Chest Surgery, JA Nagano Azumi General Hospital, Ikeda, Nagano, Japan
  • ,
  • Ryoichi Kondo, MD

      Affiliations

    • Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
  • ,
  • Masayuki Haniuda, MD

      Affiliations

    • Department of Surgery, Division of Chest Surgery, Aichi Medical University, Nagakute-cho, Aichi, Japan

Received 30 June 2009 ,Accepted 28 July 2009.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
  2. Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg. 1995;109:120–129
  3. Asamura H, Goya T, Koshiishi Y, et al. A Japanese lung cancer registry study. Prognosis of 13,010 resected lung cancers. J Thorac Oncol. 2008;3:46–52
  4. Shepherd FA, Crowley J, Van Houtte P, et al. The International Association for the Study of Lung Cancer Lung Cancer Staging Project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. J Thorac Oncol. 2007;2:1067–1077
  5. Henschke CI, Yankelevitz DF, Libby DM, et al. The International Early Lung Cancer Action Program (I-ELCAP) Investigators Survival of patients with Stage I lung cancer detected on CT screening. N Engl J Med. 2006;355:1763–1771
  6. Sone S, Nakayama T, Honda T, et al. Long-term follow-up study of a population-based 1996–1998 mass screening programme for lung cancer using mobile low-dose spiral computed tomography. Lung Cancer. 2007;58:329–341
  7. Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer. 1995;75:2844–2852
  8. Yokose T, Suzuki K, Nagai K, et al. Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinoma of the lung 3 cm or less in diameter. Lung Cancer. 2000;29:179–188
  9. Suzuki K, Yokose T, Yoshida J, et al. Prognostic significance of the size of central fibrosis in peripheral adenocarcinoma of the lung. Ann Thorac Surg. 2000;69:893–897
  10. Watanabe S-i, Oda M, Go T, et al. Should mediastinal nodal dissection be routinely be undertaken in patients with peripheral small-sized (2cm or less) lung cancer? Retrospective analysis of 225 patients. Eur J Cardiothorac Surg. 2001;20:1007–1011
  11. Gajra A, Newman N, Gamble GP, et al. Impact of tumor size on survival in stage IA non-small cell lung cancer: a case for subdividing stage IA disease. Lung Cancer. 2003;42:51–57
  12. Terasaki H, Niki T, Matsuno Y, et al. Lung adenocarcinoma with mixed bronchioloalveolar and invasive components. Am J Surg Pathol. 2003;27:937–951
  13. Funai K, Yokose T, Ishii G-i, et al. Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung. Am J Surg Pathol. 2003;27:978–984
  14. MacMahon H, Austin JHM, Gamsu G, et al. Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology. 2005;237:395–400
  15. Sone S, Takashima S, Li F, et al. Mass screening for lung cancer with mobile spiral computed tomography scanner. Lancet. 1998;351:1242–1245
  16. Sone S, Li F, Yang ZG, et al. Characteristics of small lung cancers invisible on conventional chest radiography and detected by population based screening using spiral CT. Br J Radiol. 2000;73:137–145
  17. Sone S, Li F, Yang ZG, et al. Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer. 2001;84:25–32
  18. Hasegawa M, Sone S, Takashima S, et al. Growth rate of small lung cancers detected on mass CT screening. Br J Radiol. 2000;73:1252–1259
  19. Kawakami S, Sone S, Takashima S, et al. Atypical adenomatous hyperplasia of the lung: correlation between high-resolution CT findings and histopathologic features. Eur Radiol. 2001;11:811–814
  20. Sone S, Nakayama T, Honda T, et al. CT findings of early-stage small cell lung cancer in a low-dose CT screening programme. Lung Cancer. 2007;56:207–215
  21. Aoki T, Nakata H, Watanabe H, et al. Evolution of peripheral lung adenocarcinomas: CT findings correlated with histology and tumor doubling time. Am J Roentgenol. 2000;174:763–768
  22. Reid L. The secondary lobule in the adult human lung, with special reference to its appearance in bronchograms. Thorax. 1958;13:110–115
  23. Raskin SP. The pulmonary acinus. Radiology. 1982;144:31–34
  24. Gamsu G, Thurlbeck WM, Macklem PT, et al. Roentgenographic appearance of the human pulmonary acinus. Invest Radiol. 1971;6:171–175
  25. Pump KK. Morphology of the acinus of the human lung. Chest. 1969;56:126–134
  26. Itoh H, Murata K, Konishi J, et al. Diffuse lung disease: Pathologic basis for the high resolution computed tomography findings. J Thorac Imaging. 1993;8:176–188
  27. Giovagnorio F, Cavallo V. HRCT evaluation of secondary lobules and acini of the lung. J Thorac Imaging. 1995;10:129–133
  28. Webb WR, Müller NL, Naidich DP. High-resolution CT of the lung. New York: Raven Press; 1992;
  29. Travis WD, Garg K, Franklin WA, et al. Evolving concept in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol. 2005;23:3279–3287
  30. Nakahara R, Yokose T, Nagai K, et al. Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia. Thorax. 2001;56:302–305
  31. Kim HY, Shim YM, Lee KS, et al. Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology. 2007;245:267–275
  32. Oda S, Awai K, Liu D, et al. Ground-glass opacities on thin-section helical CT: differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia. Am J Roentgenol. 2008;190:1363–1368
  33. Miller WT, Husted J, Freiman D, et al. Bronchioloalveolar carcinoma: two clinical entities with one pathologic diagnosis. Am J Roentgenol. 1978;130:905–912
  34. Hill CA. Bronchioloalveolar carcinoma: a review. Radiology. 1984;150:15–20
  35. Sakurai H, Asamura H, Watanabe S-i, et al. Clinicopathologic features of peripheral squamous cell carcinoma of the lung. Ann Thorac Surg. 2004;78:222–227

 Follow-up studies of the subjects in the computed tomography screening program was supported in part by a Gant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare, Japan (Third Term Comprehensive Control Research for Cancer; No 16271201).

PII: S1076-6332(09)00447-4

doi: 10.1016/j.acra.2009.08.003

Academic Radiology
Volume 17, Issue 1 , Pages 75-83 , January 2010