Academic Radiology
Volume 17, Issue 2 , Pages 146-156 , February 2010

Effects of CT Section Thickness and Reconstruction Kernel on Emphysema Quantification: Relationship to the Magnitude of the CT Emphysema Index

  • David S. Gierada, MD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • Corresponding Author InformationAddress correspondence to: D.S.G.
    • ,
  • Andrew J. Bierhals, MD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Cliff K. Choong, MBBS

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Seth T. Bartel, MS

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Jon H. Ritter, MD

      Affiliations

    • Department of Pathology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Nitin A. Das, MD

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Cheng Hong, MD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Thomas K. Pilgram, PhD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Kyongtae T. Bae, MD, PhD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Bruce R. Whiting, PhD

      Affiliations

    • Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Jason C. Woods, PhD

      Affiliations

    • Department of Physics, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • James C. Hogg, MD, PhD

      Affiliations

    • James Hogg iCapture Center, St. Paul's Hospital, Vancouver, BC, Canada
    • ,
  • Barbara A. Lutey, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Richard J. Battafarano, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Joel D. Cooper, MD

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • Bryan F. Meyers, MD

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105
    • ,
  • G. Alexander Patterson, MD

      Affiliations

    • Division of Cardiothoracic Surgery, 510 S. Kingshighway Blvd., Washington University, St. Louis, MO 63105

Received 24 December 2008 ,Accepted 24 August 2009.

References 

  1. Chatila WM, Hoffman EA, Gaughan J, et al. Advanced emphysema in African-American and white patients: do differences exist?. Chest. 2006;130:108–118
  2. Dransfield MT, Washko GR, Foreman MG, et al. Gender differences in the severity of CT emphysema in COPD. Chest. 2007;132:464–470
  3. Martinez FJ, Curtis JL, Sciurba F, et al. Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med. 2007;176:243–252
  4. Demeo DL, Hersh CP, Hoffman EA, et al. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007;176:42–48
  5. Ogawa E, Nakano Y, Ohara T, et al. Body mass index in male patients with chronic obstructive pulmonary disease; correlation with low attenuation areas on CT. Thorax. 2009;64:20–25
  6. Dirksen A. Progress of emphysema in severe alpha 1-antitrypsin deficiency as assessed by annual CT. Acta Radiol. 1997;38:826–832
  7. Roth MD, Connett JE, D'Armiento JM, et al. Feasibility of retinoids for the treatment of emphysema study. Chest. 2006;130:1334–1345
  8. Boschetto P, Quintavalle S, Zeni E, et al. Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax. 2006;61:1037–1042
  9. Patel BD, Coxson HO, Pillai SG, et al. Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178:500–505
  10. Gierada DS, Pilgram TK, Whiting BR, et al. Comparison of standard- and low-radiation-dose CT for quantification of emphysema. AJR Am J Roentgenol. 2007;188:42–47
  11. Madani A, De Maertelaer V, Zanen J, Gevenois PA. Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification—comparison with macroscopic and microscopic morphometry. Radiology. 2007;243:250–257
  12. Coxson HO, Rogers RM. Quantitative computed tomography of chronic obstructive pulmonary disease. Acad Radiol. 2005;12:1457–1463
  13. Friedman PJ. Imaging studies in emphysema. Proc Am Thorac Soc. 2008;5:494–500
  14. Reilly J. Using computed tomographic scanning to advance understanding of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3:450–455
  15. Kemerink GJ, Kruize HH, Lamers RJ, et al. CT lung densitometry: dependence of CT number histograms on sample volume and consequences for scan protocol comparability. J Comput Assist Tomogr. 1997;21:948–954
  16. Boedeker KL, McNitt-Gray MF, Rogers SR, et al. Emphysema: effect of reconstruction algorithm on CT imaging measures. Radiology. 2004;232:295–301
  17. Bland JM, Altman DG. Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet. 1995;346:1085–1087
  18. Guo J, Reinhardt JM, Kitaoka H, et al. Integrated system for CT-based assessment of parenchymal lung disease. IEEE Int Symp Biomed Imaging. 2002;871–874
  19. Gevenois PA, De Vuyst P, de Maertelaer V, et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med. 1996;154:187–192
  20. Madani A, Zanen J, de Maertelaer V, et al. Pulmonary emphysema: objective quantification at multi-detector row CT—comparison with macroscopic and microscopic morphometry. Radiology. 2006;238:1036–1043
  21. Muller NL, Staples CA, Miller RR, et al. “Density mask.” An objective method to quantitate emphysema using computed tomography. Chest. 1988;94:782–787
  22. Mittermayer C, Wybitul K, Rau WS, et al. Standardized fixation of human lung for radiology and morphometry; description of a “two chamber” system with formaldehyde vapor inflation. Pathol Res Pract. 1978;162:115–130
  23. Wright BM, Slavin G, Kreel L, et al. Postmortem inflation and fixation of human lungs. A technique for pathological and radiological correlations. Thorax. 1974;29:189–194
  24. Woods JC, Choong CK, Yablonskiy DA, et al. Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema. Magn Reson Med. 2006;56:1293–1300
  25. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307–310
  26. Yuan R, Mayo JR, Hogg JC, et al. The effects of radiation dose and CT manufacturer on measurements of lung densitometry. Chest. 2007;132:617–623
  27. Weibel ER, Hsia CC, Ochs M. How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol. 2007;102:459–467
  28. Mitzner W. Use of mean airspace chord length to assess emphysema. J Appl Physiol. 2008;105:1980–1981
  29. Greaves IA. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Mean airspace chord length is useful in assessing emphysema. J Appl Physiol. 1982;2008:105;author reply 1986–1987
  30. Hsia CC, Hyde DM, Ochs M, Weibel ER. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. To be or not to be-accurate. J Appl Physiol. 2008;105:1982–1983author reply 1986–1987
  31. Bates JH. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Purists versus pragmatists. J Appl Physiol. 1983;2008:105;author reply 1986–1987
  32. Rossiter HB, Breen EC. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Assessment of emphysema benefits from quantification of heterogeneity. J Appl Physiol. 2008;105:1983–1984author reply 1986–1987
  33. Parameswaran H, Majumdar A, Hamakawa H, Suki B. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Pattern of parenchymal destruction determines lung function decline. J Appl Physiol. 1984;2008:105;author reply 1986–1987
  34. Fehrenbach H. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. What does Lm tell us about lung pathology?. J Appl Physiol. 2008;105:1984–1985author reply 1986–1987
  35. Mata JF. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Mean airspace chord length and hyperpolarized gas magnetic-resonance measurements. J Appl Physiol. 1985;2008:105;author reply 1986–1987
  36. Trotta BM, Stolin AV, Williams MB, Gay SB, Brody AS, Altes TA. Characterization of the relation between CT technical parameters and accuracy of quantification of lung attenuation on quantitative chest CT. AJR Am J Roentgenol. 2007;188:1683–1690

 Current affiliations: Monash University, Australia (C.K.C); University of Chicago, Chicago, IL (C.H.); University of Pittsburgh, Pittsburgh, PA (K.T.B.); University of Maryland, Baltimore, MD (R.J.B.).

 Supported by National Institutes of Health grant R01 HL72369.

PII: S1076-6332(09)00492-9

doi: 10.1016/j.acra.2009.08.007

Academic Radiology
Volume 17, Issue 2 , Pages 146-156 , February 2010

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