Reproducibility of Lung and Lobar Volume Measurements Using Computed Tomography

Brown, Matthew S.; Kim, Hyun J.; Abtin, Fereidoun; Da Costa, Irene; Pais, Richard; Ahmad, Shama; Angel, Erin; Ni, Chiayi; Kleerup, Eric C.; Gjertson, David W.; McNitt-Gray, Michael F.; Goldin, Jonathan G.

doi:10.1016/j.acra.2009.10.005

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Volume 17, Issue 3 , Pages 316-322, March 2010

Reproducibility of Lung and Lobar Volume Measurements Using Computed Tomography

Matthew S. Brown, PhD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
- Address correspondence to: M.S.B.
Hyun J. Kim, PhD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Fereidoun Abtin, MD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Irene Da Costa
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Richard Pais, BA
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Shama Ahmad, MS
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Erin Angel, PhD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Chiayi Ni, MD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Eric C. Kleerup, MD
- Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, Los Angeles, CA
David W. Gjertson, PhD
- Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA
Michael F. McNitt-Gray, PhD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024
Jonathan G. Goldin, MD, PhD
- Thoracic Imaging Research Group, Department of Radiological Sciences, University of California, Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024

Received 29 July 2009; accepted 23 September 2009. published online 10 December 2009.

Rationale and Objectives

Lung and lobar volume measurements from computed tomographic (CT) imaging are being used in clinical trials to assess new minimally invasive emphysema treatments aiming to reduce lung volumes. Establishing the reproducibility of lung volume measurements is important if they are to be accepted as treatment planning and outcome variables. The aims of this study were to (1) investigate the correlation between lung volumes assessed on CT imaging and on pulmonary function testing (PFT), (2) compare the two methods' reproducibility, and (3) assess the reproducibility of CT lobar volumes.

Materials and Methods

CT imaging and body plethysmography were performed at baseline and after a 9-month interval in multicenter emphysema treatment trials. Lung volumes were measured at total lung capacity (TLC) and at residual volume (RV). Lobar volumes were measured on CT imaging using a semiautomated technique. The correlations between CT and PFT volumes were computed for 486 subjects at baseline. Reproducibility was assessed in terms of the intraclass correlation coefficient (ICC) for 126 subjects from the control group at TLC and 120 subjects at RV.

Results

Correlations between CT and PFT lung volumes were 0.86 at TLC and 0.67 at RV. At TLC, the ICCs were 0.943 for CT imaging and 0.814 for PFT. At RV, the ICCs were 0.886 for CT imaging and 0.683 for PFT. CT lobar volumes showed good reproducibility (all P values < .05).

Conclusion

CT lung and lobar volume measurements could be captured in a multicenter trial setting with high reproducibility and were highly correlated with those obtained on PFT. CT imaging showed significantly better reproducibility than PFT between interval lung volume measurements, offering the potential for designing emphysema treatment trials involving fewer subjects.

Key Words: Body plethysmography, emphysema, image analysis