Academic Radiology
Volume 17, Issue 3 , Pages 271-276 , March 2010

MRI-coupled Fluorescence Tomography Quantifies EGFR Activity in Brain Tumors

  • Scott C. Davis, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • Corresponding Author InformationAddress correspondence to: S.C.D.
    • ,
  • Kimberley S. Samkoe, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • ,
  • Julia A. O'Hara, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • ,
  • Summer L. Gibbs-Strauss, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Hannah L. Payne

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • ,
  • P. Jack Hoopes, PhD, DVM

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • Department of Surgery, Dartmouth Medical School, Lebanon, NH
    • ,
  • Keith D. Paulsen, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • Department of Diagnostic Radiology, Dartmouth Medical School, Lebanon, NH
    • ,
  • Brian W. Pogue, PhD

      Affiliations

    • Thayer School of Engineering, Dartmouth College, HB 8000, Hanover NH 03755
    • Department of Surgery, Dartmouth Medical School, Lebanon, NH

Received 30 September 2009 ,Accepted 5 November 2009.

References 

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  13. Patwardhan SV, Bloch SR, Achilefu S, et al. Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Opt Exp. 2005;13:2564–2577
  14. Davis SC, Pogue BW, Springett R, et al. Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue. Rev Sci Instr. 2008;79:064302–1 to -10
  15. McCann CM, Waterman P, Figueiredo J-L, et al. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009;45:360–369
  16. Arridge SR, Schweiger M. Photon-measurement density functions. Part 2: finite-element-method calculations. Appl Opt. 1995;34:8026–8037
  17. Davis SC, Dehghani H, Wang J, et al. Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization. Optics Exp. 2007;15:4066–4082
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 Funded by the National Institutes of Health grants RO1 CA109558, RO1 CA69544, and Philips Research Hamburg, Department of Defense Breast Cancer pre-doctoral fellowship BC051058.

PII: S1076-6332(09)00622-9

doi: 10.1016/j.acra.2009.11.001

Academic Radiology
Volume 17, Issue 3 , Pages 271-276 , March 2010

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