Academic Radiology
Volume 17, Issue 9 , Pages 1128-1135 , September 2010

Lung Growth in Infants and Toddlers Assessed by Multi-slice Computed Tomography

  • Laxmi Rao, MD

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • Christina Tiller, RRT

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • Cathy Coates, RN

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • Risa Kimmel, RN

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • Kimberly E. Applegate, MD, MS

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • Janice Granroth-Cook, BS

      Affiliations

    • Department of Radiology, Iowa Children's Hospital, Iowa City, IA
    • ,
  • Cheryl Denski, MS

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • ,
  • James Nguyen, MS

      Affiliations

    • Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Zhangsheng Yu, PhD

      Affiliations

    • Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Eric Hoffman, MD

      Affiliations

    • Department of Radiology, Iowa Children's Hospital, Iowa City, IA
    • ,
  • Robert S. Tepper, MD, PhD

      Affiliations

    • Department of Pediatrics, James Whitcomb Riley Hospital for Children, Herman B. Wells Center for Pediatric Research, Indiana University, 702 Barnhill Drive, ROC 4270, Indianapolis, IN 46202-5225
    • Corresponding Author InformationAddress correspondence to: R.S.T.

Received 8 March 2010 ,Accepted 12 April 2010.

References 

  1. Hislop AA, Wigglesworth JS, Desai R. Alveolar development in the human fetus and infant. Early Hum Devel. 1986;13:1–11
  2. Thurlbeck WM. Post natal growth and development of the lung. Am Rev Respir Dis. 1975;111:803–844
  3. Zeltner TB, Burri PH. The postnatal development and growth of the human lung. II. Morphology. Respir Physiol. 1987;67:269–282
  4. Zeltner TB, Caduff JH, Gehr P, et al. The postnatal development and growth of the human lung. I. Morphometry. Respir Physiol. 1987;67:247–267
  5. Davies G, Reid L. Growth of the alveoli and pulmonary arteries in childhood. Thorax. 1970;25:669–681
  6. Dunnill MS. Postnatal growth of the lung. Thorax. 1962;17:329–333
  7. Hislop A, Muir DCF, Jacobsen M, et al. Postnatal growth and function of the pre-acinar airways. Thorax. 1972;27:265–274
  8. Horsfield K, Gordon WI, Kemp W, et al. Growth of the bronchial tree in man. Thorax. 1987;42:383–388
  9. Washko GR, Criner GJ, Mohsenifar Z, et al. Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics. Chron Obstr Pulmon Dis. 2008;5:177–186
  10. de Blic J, Tillie-Leblond I, Emond S, et al. High-resolution computed tomography scan and airway remodeling in children with severe asthma. J Allerg Clin Immunol. 2005;116:750–754
  11. Nakano Y, Muller NL, King GG, et al. Quantitative assessment of airway remodeling using high-resolution CT. Chest. 2002;122(suppl):275S
  12. de Jong PA, Nakano Y, Hop WC, et al. Changes in airway dimensions on computed tomography scans of children with cystic fibrosis. Am J Respir Crit Care Med. 2005;172:218–224
  13. Hislop AA. Lung growth and computed tomography. Eur Respir J. 2003;22:195–196
  14. de Jong PA, Nakano Y, Lequin MH, et al. Estimation of lung growth using computed tomography. Eur Respir J. 2003;22:235–238
  15. de Jong PA, Long FR, Wong JC, et al. Computed tomographic estimation of lung dimensions throughout the growth period. Eur Respir J. 2006;27:261–267
  16. Long FR, Williams RS, Castile RG. Inspiratory and expiratory CT lung density in infants and young children. Pediatr Radiol. 2005;35:677–683
  17. Long FR. High-resolution CT of the lungs in infants and young children. J Thorac Imaging. 2001;16:251–258
  18. Martinez TM, Llapur CJ, Williams TH, et al. High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis. Am J Respir Crit Care Med. 2005;172:1133–1138
  19. Tschirren J, Pal Gyi K, Reinhardt JM, et al. Segmentation, skeletonization, and branchpoint matching—a fully automated quantitative evaluation of human intrathoracic airway trees. Berlin, Germany: Springer-Verlag; 2002;12–19
  20. Tschirren J, McLennan G, Palagyi K, et al. Matching and anatomical labeling of human airway tree. IEEE Trans Med Imaging. 2005;24:1540–1547
  21. Pagano M, Gauvereau . Principles of biostatistics. 2nd ed.. Pacific Grove, CA: Duxbury; 2000;
  22. Coppoletta JM, Wolbach SB. Body length and organ weights of infants and children: a study of the body length and normal weights of the more important vital organs of the body between birth and twelve years of age. Am J Pathol. 1933;9:55–70
  23. Bucci G, Cook CD, Barrie H. Studies of respiratory physiology in children: total lung diffusion, diffusing capacity of pulmonary membrane, and pulmonary capillary blood volume in normal subjects from 7 to 40 years of age. J Pediatr. 1961;58:820–828
  24. Stigol LC, Vawter GF, Mead J. Studies on elastic recoil of the lung in a pediatric population. Am Rev Respir Dis. 1972;105:552–563
  25. Balinotti JE, Tiller CJ, Llapur CJ, et al. Growth of the lung parenchyma early in life. Am J Respir Crit Care Med. 2009;179:134–137
  26. Davis S, Jones M, Kisling J, et al. Density dependence of forced expiratory flows in healthy infants and toddlers. J Appl Physiol. 1999;87:1796–1801
  27. Jones M, Castile R, Davis S, et al. Forced expiratory flows and volumes in infants. Normative data and lung growth. Am J Respir Crit Care Med. 2000;161:353–359
  28. Hammer J, Numa A, Newth CJ. Total lung capacity by N2 washout from high and low lung volumes in ventilated infants and children. Am J Respir Crit Care Med. 1998;158:526–531
  29. Tepper RS, Hiatt PW, Eigen H, et al. Total respiratory system compliance in asymptomatic infants with cystic fibrosis. Am Rev Respir Dis. 1987;135:1075–1079
  30. Tepper RS, Williams T, Kisling J, et al. Static compliance of the respiratory system in healthy infants. Am J Respir Crit Care Med. 2001;163:91–94
  31. Brown RH, Mitzner W, Wagner E, et al. Airway distension with lung inflation measured by HRCT1. Acad Radiol. 2003;10:1097–1103
  32. Shen X, Ramchandani R, Dunn B, et al. Effect of transpulmonary pressure on airway diameter and airway responsiveness of immature and mature rabbits. J Appl Physiol. 2000;89:1584–1590

 This study was supported by grant HL054062 from the National Institutes of Health (Bethesda, MD).

PII: S1076-6332(10)00233-3

doi: 10.1016/j.acra.2010.04.012

Academic Radiology
Volume 17, Issue 9 , Pages 1128-1135 , September 2010

Article Tools

* Image Usage & Resolution