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): Figure 1. P730 Gd is a precursor in the synthesis of new macromolecular MRI contrast agents.
The inner sphere contribution to the relaxivity of gadolinium complexes is determined
by the rotational correlation time of the complex τR, the water residence time τM in the first coordination shell and the electronic relaxation time τS (
). Each of these main relaxometric parameters is influenced by the structural characteristics
of the complexes. Consequently, the structural and the physicochemical properties
of each P730 diastereoisomer have been studied by crystallography, NMR and luminescence.
In order to avoid complex dissociation, new Gd3+ chelates should be characterized by high thermodynamic stability and transmetallation
inertness, therefore the thermodynamic stability constant of P730 Gd was determined
and its stability in a model of transmetallation was assessed.
Lanthanide ion probes of structure in biology. Laser-induced luminescence decay constants provide a direct measure of the number of metal-coordinated water molecules.
Correlation of water exchange rate with isomeric composition in diastereoisomeric gadolinium complexes of tetra(carboxyethyl)dota and related macrocyclic ligands.
Structure and dynamics of all of the stereoisomers of europium complexes of tetra(carboxyethyl) derivatives of dota: ring inversion is decoupled from cooperative arm rotation in the RRRR and RRRS isomers.
Study of formation of complexes in aqueous solutions. III. A new method for refinement of stability constants of complexes and other parameters of protometric titrations.
