Rationale and Objectives
To prospectively analyze the correlation between parameters of liver perfusion from
technetium99m-macroaggregates of albumin (99mTc-MAA) single photon emission computed tomography (SPECT) with those obtained from
dynamic CT perfusion in patients with primary or metastatic liver malignancy.
Materials and Methods
Twenty-five consecutive patients (11 women, 14 men; mean age 60.9 ± 10.8; range: 32–78
years) with primary (n = 5) or metastatic (n = 20) liver malignancy planned to undergo selective internal radiotherapy underwent
dynamic contrast-enhanced CT liver perfusion imaging (four-dimensional spiral mode,
scan range 14.8 cm, 15 scans, cycle time 3 seconds) and 99mTc-MAA SPECT after intraarterial injection of 180 MBq 99mTc–MAA on the same day. Data were evaluated by two blinded and independent readers
for the parameters arterial liver perfusion (ALP), portal venous perfusion (PVP),
and total liver perfusion (TLP) from CT, and the 99mTc-MAA uptake-ratio of tumors in relation to normal liver parenchyma from SPECT.
Results
Interreader agreements for quantitative perfusion parameters were high for dynamic
CT (r = 0.90–0.98, each P < .01) and 99mTc -MAA SPECT (r = 0.91, P < .01). Significant correlation was found between 99mTc-MAA uptake ratio and ALP (r = 0.7, P < .01) in liver tumors. No significant correlation was found between 99mTc-MAA uptake ratio, PVP (r = −0.381, P = .081), and TLP (r = 0.039, P = .862).
Conclusion
This study indicates that in patients with primary and metastatic liver malignancy,
ALP obtained by dynamic CT liver perfusion significantly correlates with the 99mTc-MAA uptake ratio obtained by SPECT.
Key Words
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Article Info
Publication History
Published online: January 30, 2012
Accepted:
December 29,
2011
Received:
November 21,
2011
Footnotes
N.S. and H.A. contributed equally to this article.
Identification
Copyright
© 2012 AUR. Published by Elsevier Inc. All rights reserved.
