Rationale and Objectives
The treatment of nonmelanoma skin cancer (NMSC) is usually by surgical excision or
Mohs micrographic surgery and alternatively may include photodynamic therapy (PDT).
To guide surgery and to optimize PDT, information about the tumor structure, optical
parameters, and vasculature is desired.
Materials and Methods
Spatial frequency domain imaging (SFDI) can map optical absorption, scattering, and
fluorescence parameters that can enhance tumor contrast and quantify light and photosensitizer
dose. High frequency ultrasound (HFUS) imaging can provide high-resolution tumor structure
and depth, which is useful for both surgery and PDT planning.
Results
Here, we present preliminary results from our recently developed clinical instrument
for patients with NMSC. We quantified optical absorption and scattering, blood oxygen
saturation (StO2), and total hemoglobin concentration (THC) with SFDI and lesion thickness with ultrasound.
These results were compared to histological thickness of excised tumor sections.
Conclusions
SFDI quantified optical parameters with high precision, and multiwavelength analysis
enabled 2D mappings of tissue StO2 and THC. HFUS quantified tumor thickness that correlated well with histology. The
results demonstrate the feasibility of the instrument for noninvasive mapping of optical,
physiological, and ultrasound contrasts in human skin tumors for surgery guidance
and therapy planning.
Key Words
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Article Info
Publication History
Accepted:
November 18,
2013
Received:
August 16,
2013
Identification
Copyright
© 2014 AUR. Published by Elsevier Inc. All rights reserved.
