Rationale and Objectives
To evaluate the ability of segmental linear fitting analysis of gadolinium ethoxybenzyl
diethylenetriamine pentaacetic acid liver perfusion magnetic resonance imaging (MRI)
to assess liver function and liver fibrosis.
Materials and Methods
Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid liver perfusion MRI was
performed in 41 patients, and perfusion estimates were generated by segmental linear
fitting analysis of the time-intensity curves. The relationships of Tin, Tout, Kup, and the ratio between the signal intensities of the peak and the last phase with
liver fibrosis stage and laboratory measurements of liver function were evaluated.
Results
Serum prealbumin concentration was significantly positively correlated with Kup and the signal intensity ratio and was significantly negatively correlated with Tin and Tout. Tin and Tout were significantly higher and Kup and the signal intensity ratio were significantly lower in patients with advanced
fibrosis than those without. Tout was the best predictor of advanced fibrosis, with an area under the receiving operating
characteristic curve of 0.843, a sensitivity of 100%, and a specificity of 80%.
Conclusions
A new procedure of quantifying the hepatocyte-specific uptake of a T1-enhancing contrast
agent can be used to assess impaired hepatobiliary function. The parameters obtained
from perfusion MRI have the potential to predict advanced fibrosis.
Key Words
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Article info
Publication history
Published online: January 16, 2015
Accepted:
November 8,
2014
Received:
September 13,
2014
Footnotes
Sheng Xie and Yongliang Sun contributed equally to this work.
Disclosure: The authors have declared that no competing interests exist.
Identification
Copyright
© 2015 AUR. Published by Elsevier Inc. All rights reserved.
