That overdiagnosis exists in any type of cancer screening is not a point of contention,
as I discussed in my article (
1
). It is an inexorable consequence of our incomplete knowledge of the biological behavior
of premalignant and malignant lesions and of the fundamental limitation that we cannot,
by definition, predict random events. The relevant issues are how to estimate its
magnitude and what solutions can be envisioned to reduce it. Measuring overdiagnosis
is not a simple task, and clinical trial choices and assumptions dramatically influence
its estimate (
1
).To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: October 27, 2015
Footnotes
In reply to Fitzgerald.
Identification
Copyright
© 2016 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
