Rationale and Objectives
Resting-state (RS) networks, revealed by functional magnetic resonance imaging (fMRI)
studies in healthy volunteers, have never been evaluated in anesthetized patients
with brain tumors. Our purpose was to examine the presence of residual brain activity
on the auditory network during propofol-induced loss of consciousness in patients
with brain tumors.
Materials and Methods
Twenty subjects with intracranial masses were prospectively studied by means of intraoperative
RS-fMRI acquisitions before any craniectomy. After performing single-subject independent
component analysis, spatial maps and time courses were assigned to an auditory RS
network template from the literature and compared via spatial regression coefficients.
Results
All fMRI data were of sufficient quality for further postprocessing. In all but two
patients, the RS functional activity of the auditory network could be successfully
mapped. In almost all patients, contralateral activation of the auditory network was
present. No significant difference was found between the mean distance of the RS activity
clusters and the lesion periphery for tumors located in the temporal gyri vs. those
in other brain regions. The spatial deviation between the activated cluster in our
experiment and the template was significantly (P = 0.04) higher in patients with tumors located in the temporal gyri than in patients
with tumors located in other regions.
Conclusions
Propofol-induced anesthesia in patients with intracranial lesions does not alter the
blood-oxygenation level-depended signal, and independent component analysis of intraoperative
RS-fMRI may allow assessment of the auditory network in a clinical setting.
Key Words
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Article info
Publication history
Published online: November 25, 2015
Accepted:
October 13,
2015
Received in revised form:
October 11,
2015
Received:
April 13,
2015
Identification
Copyright
© 2015 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
