Advertisement

Comparison of Abbreviated MRI with Mammography and Ultrasound in Women with a Personal History of Breast Cancer

      Rationale and Objectives

      To compare abbreviated MRI with mammography and US for screening in women with a personal history of breast cancer. In addition, the first and subsequent rounds of abbreviated MRI were compared.

      Materials and Methods

      The Institutional Review Board approved this retrospective study. Nine hundred and thirty-nine abbreviated MRI scans of 710 women with a personal history of breast cancer were included (mean age, 54.1±9.4 years). The diagnostic performances of abbreviated MRI, mammography, and US for the detection of the second breast cancer were compared. When more than one round of abbreviated MRI was performed, we compared the scans of the first and subsequent rounds.

      Results

      There were 15 (2.1%) cases of second breast cancer. Thirty-nine of the 939 abbreviated MRI scans were diagnosed as positive; of them, 11 were diagnosed as breast cancer, with a PPV2 of 28.2% (US, 19.0%; mammography, 28.6%). The AUC, sensitivity, and cancer detection rate (per 1000) were the highest for abbreviated MRI (0.829, 68.8% and 11.7) (US: 0.616, 25.0%, and 4.3; mammography: 0.560, 12.5%, and 2.1, respectively). Two hundred women underwent multiple rounds of abbreviated MRI. AUC, PPV2, and the cancer detection rates were higher during the subsequent rounds (0.987, 45.5, and 21.8) than during the first round (0.605, 11.1, and 5).

      Conclusion

      Abbreviated MRI for women with a personal history of breast cancer was more sensitive for the diagnosis of second breast cancer than US or mammography. In addition, subsequent rounds of MRI showed better performance than the first round.

      Key Words

      Abbreviations:

      BCS (breast conserving surgery), MIP (maximum intensity projection), BI-RADS (Breast Imaging Reporting and Data System), IDC (invasive ductal carcinoma), DCIS (ductal carcinoma in situ)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Academic Radiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      REFERENCES

        • Gao X
        • Fisher SG
        • Emami B.
        Risk of second primary cancer in the contralateral breast in women treated for early-stage breast cancer: a population-based study.
        Int J Radiat Oncol Biol Phys. 2003; 56: 1038-1045
        • Veronesi U
        • Cascinelli N
        • Mariani L
        • et al.
        Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.
        The New England journal of medicine. 2002; 347: 1227-1232
        • Nichols HB
        • Berrington de Gonzalez A
        • Lacey Jr., JV
        • Rosenberg PS
        • Anderson WF
        Declining incidence of contralateral breast cancer in the United States from 1975 to.
        Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2006; 29: 1564-1569
        • Lam DL
        • Houssami N
        • Lee JM.
        Imaging Surveillance After Primary Breast Cancer Treatment.
        AJR American journal of roentgenology. 2017; 208: 676-686
        • Buchanan CL
        • Dorn PL
        • Fey J
        • et al.
        Locoregional recurrence after mastectomy: incidence and outcomes.
        J Am Coll Surg. 2006; 203: 469-474
        • van Dongen JA
        • Voogd AC
        • Fentiman IS
        • et al.
        Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial.
        Journal of the National Cancer Institute. 2000; 92: 1143-1150
        • Early Breast Cancer Trialists' Collaborative G
        • Darby S
        • McGale P
        • et al.
        Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials.
        Lancet (London, England). 2011; 378: 1707-1716
        • Houssami N
        • Ciatto S
        • Martinelli F
        • Bonardi R
        • Duffy SW.
        Early detection of second breast cancers improves prognosis in breast cancer survivors.
        Annals of oncology: official journal of the European Society for Medical Oncology /ESMO. 2009; 20: 1505-1510
        • Berg WA
        • Zhang Z
        • Lehrer D
        • et al.
        Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk.
        Jama. 2012; 307: 1394-1404
        • Ozaki S
        • Tozaki M
        • Fukuma E
        • et al.
        Bilateral breast MR imaging: is it superior to conventional methods for the detection of contralateral breast cancer?.
        Breast Cancer. 2008; 15: 169-174
        • Gweon HM
        • Cho N
        • Han W
        • et al.
        Breast MR imaging screening in women with a history of breast conservation therapy.
        Radiology. 2014; 272: 366-373
        • Cho N
        • Han W
        • Han BK
        • et al.
        Breast Cancer Screening With Mammography Plus Ultrasonography or Magnetic Resonance Imaging in Women 50 Years or Younger at Diagnosis and Treated With Breast Conservation Therapy.
        JAMA Oncol. 2017; 3: 1495-1502
        • Lehman CD
        • Lee JM
        • DeMartini WB
        • et al.
        Screening MRI in Women With a Personal History of Breast Cancer.
        Journal of the National Cancer Institute. 2016; 108
        • Kuhl CK
        • Schrading S
        • Strobel K
        • et al.
        Abbreviated breast magnetic resonance imaging (MRI): first postcontrast subtracted images and maximum-intensity projection-a novel approach to breast cancer screening with MRI.
        J Clin Oncol. 2014; 32: 2304-2310
        • Panigrahi B
        • Mullen L
        • Falomo E
        • et al.
        An Abbreviated Protocol for High-risk Screening Breast Magnetic Resonance Imaging: Impact on Performance Metrics and BI-RADS Assessment.
        Academic radiology. 2017; 24: 1132-1138
        • Choi BH
        • Choi N
        • Kim MY
        • et al.
        Usefulness of abbreviated breast MRI screening for women with a history of breast cancer surgery.
        Breast cancer research and treatment. 2018; 167: 495-502
        • Ha T
        • Jung Y
        • Kim J
        • Park S
        • et al.
        Comparison of the diagnostic performance of abbreviated MRI and full diagnostic MRI using a computer-aided diagnosis (CAD) system in patients with a personal history of breast cancer: the effect of CAD-generated kinetic features on reader performance.
        Clinical radiology. 2019; 74 (e15-e21): 817
        • Pages EB
        • Millet I
        • Hoa D
        • et al.
        Undiagnosed breast cancer at MR imaging: analysis of causes.
        Radiology. 2012; 264: 40-50