Rationale and objectives
To evaluate liver perfusion changes and their effect on liver regeneration (LR) after
partial hepatectomy (PH) using intravoxel incoherent motion (IVIM) and T2* mapping
in a rat model.
Methods
One hundred and two rats underwent 30%, 50%, or 70% PH. Within each group (n = 34), rats in MR imaging subgroup (n = 10) underwent liver IVIM and T2* mapping before and within 2 h, 1, 2, 3, 5, 7,
14, and 21 days post-PH to measure D*, perfusion fraction (PF), and T2* values. Three
rats from histologic subgroup (n = 24) sacrificed at each time point for hepatocyte Ki-67 indices and diameters measurement.
Results
Liver D* and PF values decreased immediately post-PH, then returned to original level
as LR progressed in all groups. PF values in 70% PH group were significantly lower
than in the other two groups (p < .05). D* and PF values correlated significantly with hepatocyte Ki-67 indices (r = –0.588 to –0.915; p < .05) and hepatocyte diameter (r = –0.555 to –0.792; p < .05). Liver T2* values decreased immediately within 2 h post-PH, then increased
to a high level and followed with returning to original level gradually. The duration
of the high T2* levels was consistent with Ki-67 indices.
Conclusions
Liver perfusion decreased immediately followed with increasing gradually after PH.
IVIM and T2* mapping are promising methods for monitoring changes of liver perfusion.
IVIM-derived D* value is the best indicator in reflecting the process of LR noninvasively.
Keywords
Abbreviations:
FOV (field of view), ICC (intraclass correlation coefficient), IVIM (intravoxel incoherent motion), LR (liver regeneration), MRI (magnetic resonance imaging), PF (perfusion fraction), PH (partial hepatectomy), ROI (region of interest), SD (standard deviation), TE (echo time), TR (repetition time), WI (weighted imaging)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: July 20, 2022
Accepted:
April 19,
2022
Received in revised form:
March 13,
2022
Received:
November 27,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Published by Elsevier Inc. on behalf of The Association of University Radiologists.
