I read with great interest the excellent article by He et al., which reported pancreatic
disease entities other than autoimmune pancreatitis in patients with diffuse involvement
of pancreas shown on CT (
1
). In particular, He et al. reported that 4.5% of cases of diffuse involvement of
pancreas (11/245) are due to pancreatic neuroendocrine tumor. I wish to complement
the article by pointing out that Mahvash disease, an autosomal recessive pancreatic
neuroendocrine tumor syndrome, clearly exhibits diffuse involvement of pancreas on
imaging (
2
,
3
) and could be the underlying specific diagnosis of at least a few of the 11 cases
of pancreatic neuroendocrine tumor with diffuse involvement of pancreas reported by
He et al. (
1
).To read this article in full you will need to make a payment
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REFERENCES
- Diffuse involvement of pancreas is not always autoimmune pancreatitis.Acad Radiol. 2022; 9 (MarS1076-6332(22)00063-0. Epub ahead of print)
- Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor.Pancreas. 2009; 38: 941-946
- Mahvash Disease: 10 years after discovery.Pancreas. 2018; 47: 511-515
- Hypercalcemia in glucagon cell hyperplasia and neoplasia (Mahvash Syndrome): a new association.J Clin Endocrinol Metab. 2018; 103: 3119-3123
- Pancreatic neuroendocrine tumor with atypical radiologic presentation.Radiol Case Rep. 2015; 3: 162
- Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas.BJR Case Rep. 2017; 320170015
- Diffuse pancreatic neuroendocrine tumor: a rare presentation.Indian J Nucl Med. 2018; 33: 364-365
- Pancreatic neuroendocrine tumor presenting as a diffuse pancreatic enlargement, case report and review of literature.Radiology Case. 2021; 15: 11-20
Article info
Publication history
Published online: September 05, 2022
Accepted:
August 4,
2022
Received:
March 22,
2022
Footnotes
The author does not receive any grants or fellowships supporting the writing of the paper.
Identification
Copyright
© 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
