Neoadjuvant chemotherapy (NAC) is an important part of breast cancer therapy with
the advantages of contributing to better survival and downstaging cancer to increase
the chances of surgery or breast-conserving surgery (
1
,
- Teshome M
- Hunt KK.
Neoadjuvant therapy in the treatment of breast cancer.
Surg Oncol. 2014; 23 (Epub 2014 Apr 24. PMID: 24882348; PMCID: PMC4044615): 505-523https://doi.org/10.1016/j.soc.2014.03.006
2
). However, patients with chemotherapy resistance cannot benefit from NAC and may
suffer from adverse reactions due to unnecessary chemotherapy. Furthermore, the timing
of the operation may be delayed. Previous investigations demonstrated that the overall
response rate for NAC can range from 69%‒100%, with pathological complete response
being observed in 10%‒15% of patients (
3
). Therefore, a practical approach for the early evaluation and prediction of pathological
response to NAC in breast cancer is of great importance for the optimization of therapy.Keywords
Abbreviations:
AUC (area under the ROC), HR (hormonal receptor), MHR (major histological response), NAC (neoadjuvant chemotherapy), NHR (non-major histological response), Ppredictor (ROC receiver operating characteristic), ROI (region of interest), SWE (shear wave elastography), SWV (shear wave velocity), UE (Ultrasound elastography), US (Ultrasound)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 28, 2022
Accepted:
September 13,
2022
Received in revised form:
August 25,
2022
Received:
August 2,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
