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Radiological Features of Bone Lymphoma on CT and MRI. A Retrospective Monocentric Series of 56 Patients

  • Phuong Thao Nguyen
    Affiliations
    Department of Musculoskeletal Radiology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France
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  • Elodie Sibileau
    Affiliations
    Department of Musculoskeletal Radiology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France
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  • Marc Polivka
    Affiliations
    deceased Marc Polivka, Department of Pathology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France

    Department of Pathology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France
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  • Grégoire Attané
    Affiliations
    Department of Musculoskeletal Radiology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France

    B3OA, CNRS UMR 7052, Faculté de Médecine Paris Cité, Site Villemin, Paris, France
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  • Valérie Bousson
    Correspondence
    Address correspondence to: Valérie Bousson, MD, PhD, Service de Radiologie OstéoArticulaire, Hôpital Lariboisière-Fernand Widal, APHP.Nord Univeristé Paris Cité, 2 rue Ambroise Paré, 75010 Paris, France
    Affiliations
    Department of Musculoskeletal Radiology, Lariboisiere hospital, AP-HP.Nord-University Paris Cité, Paris, France

    B3OA, CNRS UMR 7052, Faculté de Médecine Paris Cité, Site Villemin, Paris, France
    Search for articles by this author
Published:October 31, 2022DOI:https://doi.org/10.1016/j.acra.2022.10.007
      Bone lymphoma is a rare bone neoplasm consisting of malignant lymphoid cells. It is classified as primary bone lymphoma (PBL) or secondary bone lymphoma (SBL). PBL is a neoplasm producing one or more tumor masses within the bone, with no extra-regional lymph-node involvement or other extranodal lesions (
      • Cleven AHG
      • Ferry JA.
      Primary non-Hodgkin lymphoma of bone.
      ). It accounts for approximately 7% of all malignant bone tumors (
      • Cleven AHG
      • Ferry JA.
      Primary non-Hodgkin lymphoma of bone.
      ,
      • Bhagavathi S
      • Micale MA
      • Les K
      Primary bone diffuse large B-cell lymphoma: clinicopathologic study of 21 cases and review of literature.
      ). SBL is a bone lymphoma with systemic disease (
      • Cleven AHG
      • Ferry JA.
      Primary non-Hodgkin lymphoma of bone.
      ). The diagnosis of bone lymphoma requires histopathologic analysis of a tumoral tissue sample. However, there is risk of a negative biopsy, especially with bone tissue biopsy, because bone lymphomas consist of loose tissue with areas of necrosis, prone to crush artifacts and fragmentation during preparation, which may interfere with immunohistochemical analysis (
      • Kitsoulis P
      • Vlychou M
      • Papoudou-Bai A
      • et al.
      Primary lymphomas of bone.
      ).

      Keywords

      Abbreviations:

      DLBCL (diffuse large B-cell lymphoma), IQR (interquartile range), PBL (primary bone lymphoma), RAP (radiologically aggressive presentation), RNAP (radiologically non-aggressive presentation), SBL (secondary bone lymphoma), SD (standard deviation), SUVmax (maximal standardized uptake value)
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