Rationale and Objectives
Lymphovascular invasion (LVI) plays an important role in the prediction of metastasis
and prognosis in breast cancer (BC) patients. The present study assessed correlations
between preoperative breast MRI, clinical features, and LVI in patients with invasive
ductal carcinoma (IDC) and identified risk factors based on these correlation factors.
Materials and Methods
Patients confirmed with IDC between 01/2012 and 12/2021 were retrospectively reviewed
at our hospital. A total of 5 clinical and 14 MRI features to characterize tumours
were extracted. LVI evaluated in hematoxylin and eosin sections. T-test and chi-square tests were used to compare the differences in clinical and MRI
features between the LVI positive and negative groups. The associations between individual
features and LVI were analysed by univariable logistic regression analysis, and risk
factors for LVI were identified by multivariable logistic regression analysis based
on these correlation factors.
Results
This study included 353 patients with IDC, including 130 with positive LVI. Age, CEA,
CA-153, amount of fibroglandular tissue (FGT), background parenchymal enhancement,
tumour size, shape, skin thickening, nipple retraction, adjacent vessel sign, and
axillary lymph node (ALN) size in the LVI positive group were significantly different
from the LVI negative group (all p<0.05). Multivariate logistic regression analysis revealed that age (odds ratio OR = 1.030),
CA-153 (OR = 1.018), heterogeneous FGT (OR = 2.484), shape (OR = 2.157), and ALN size
(OR = 1.051) were risk factors for LVI (all p<0.05).
Conclusion
Preoperative breast MRI and clinical features correlated with LVI, age, CA-153, heterogeneous
FGT, shape, and ALN size are risk factors for LVI in patients with IDC.
Key Words
Abbreviations:
BC (Breast cancer), LVI (Lymphovascular invasion), IDC (Invasive ductal carcinoma), CEA (Carcinoembryonic antigen), CA15-3 (Cancer antigen 15-3), FS-T2WI (Fat-suppressed-T2-weighted images), BI-RADS (Breast Imaging Reporting and Data System), FGT (Fibroglandular tissue), BPE (Background parenchymal enhancement), ALN (Axillary lymph node), OR (Odds ratio), CI (confidence interval)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 19, 2022
Accepted:
October 30,
2022
Received in revised form:
October 10,
2022
Received:
August 31,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
