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Using Radiomics to Detect Subtle Architecture Changes of Cartilage and Subchondral Bone in Chronic Lateral Ankle Instability Patients Based on MRI PD-FS Images

  • Author Footnotes
    ⁎⁎ The first two authors (Hongyue Tao and Yibo Dan) contributed equally to this manuscript.
    Hongyue Tao
    Footnotes
    ⁎⁎ The first two authors (Hongyue Tao and Yibo Dan) contributed equally to this manuscript.
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Author Footnotes
    ⁎⁎ The first two authors (Hongyue Tao and Yibo Dan) contributed equally to this manuscript.
    Yibo Dan
    Footnotes
    ⁎⁎ The first two authors (Hongyue Tao and Yibo Dan) contributed equally to this manuscript.
    Affiliations
    Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
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  • Yiwen Hu
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Yuxue Xie
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Rong Lu
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Xiangwen Li
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Chenglong Wang
    Affiliations
    Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
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  • Chengxiu Zhang
    Affiliations
    Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
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  • Weiwei Wang
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,
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  • Author Footnotes
    # The two authors (Guang Yang and Shuang Chen) contributed equally to this manuscript.
    Guang Yang
    Footnotes
    # The two authors (Guang Yang and Shuang Chen) contributed equally to this manuscript.
    Affiliations
    Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
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  • Author Footnotes
    # The two authors (Guang Yang and Shuang Chen) contributed equally to this manuscript.
    Shuang Chen
    Correspondence
    Address correspondence to: S.C.
    Footnotes
    # The two authors (Guang Yang and Shuang Chen) contributed equally to this manuscript.
    Affiliations
    Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai, 200040, China,

    National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University,12 Wulumuqizhong Road, Shanghai, 200040, China
    Search for articles by this author
  • Author Footnotes
    ⁎⁎ The first two authors (Hongyue Tao and Yibo Dan) contributed equally to this manuscript.
    # The two authors (Guang Yang and Shuang Chen) contributed equally to this manuscript.
Published:December 02, 2022DOI:https://doi.org/10.1016/j.acra.2022.11.014

      Rationale and Objectives

      To use radiomics to detect the subtle changes of cartilage and subchondral bone in chronic lateral ankle instability (CLAI) patients based on MRI PD-FS images.

      Materials and Methods

      A total of 215 CLAI patients and 186 healthy controls were included and randomly split into a training set (n=281, patients/controls=151/130) and an independent test set (n=120, patients/controls=64/56). They underwent ankle MRI examinations. On sagittal PD-FS images, eight cartilage regions and their corresponding subchondral bone regions were drawn. Radiomics models of cartilage, subchondral bone and combined cartilage and subchondral bone were built to differentiate CLAI patients from controls. A receiver operating characteristic curve (ROC) was used to assess the model's performance.

      Results

      In the test dataset, the cartilage model yielded an area under the curve (AUC) of 0.0.912 (95% confidence interval (CI): 0.858-0.965, p<0.001), a sensitivity of 0.859, a specificity of 0.893, a negative predictive value (NPV) of 0.848, and a positive predictive value (PPV) of 0.902. The subchondral bone model yielded an AUC of 0.837 (95% CI: 0.766-0.907, p<0.001), a sensitivity of 0.875, a specificity of 0.714, an NPV of 0.833, and a PPV of 0.778. For the combined model, the AUC was 0.921 (95% CI: 0.863-0.972, p<0.001), sensitivity was 0.844, specificity was 0.911, NPV was 0.836, and PPV was 0.915, whose AUC was higher than those of both the cartilage model and the subchondral bone model.

      Conclusion

      The combined radiomics model achieved satisfying performance in detecting potential early architectural changes in cartilage and subchondral bone for CLAI patients.

      Keywords

      Abbreviations:

      CLAI (chronic lateral ankle instability), PD-FS (proton density with fat-suppression), ROC (Receiver operating characteristic curve), AUC (area under curve), CI (confidence interval), NPV (negative predictive value), PPV (positive predictive value), ATFL (anterior talofibular ligament), CFL (calcaneofibular ligament), OA (osteoarthritis), T1WI (T1-weighted imaging), T2WI (T2-weighted imaging), BMI (body mass index), OCL (osteochondral lesion), pSTJ (posterior subtalar joints), C-S (cartilage and subchondral), SMOTE (Synthetic Minority Oversampling Technique), PCC (Pearson Correlation Coefficient), RFE (Recursive Feature Elimination), SVM (support vector machine)
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