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Perspective|Articles in Press

Specialty Society Support for Multicenter Research in Artificial Intelligence

Published:February 20, 2023DOI:https://doi.org/10.1016/j.acra.2023.01.010
      Multicenter clinical trials in radiology have long been a mainstay in our ability to translate clinical research to widespread clinical practice. They help ensure that promising results obtained by a single academic institution will generalize to the diversity of patients, imaging equipment and practice types present in the wider community. Multicenter studies reduce potential biases that may result from single institution results, promote health equity, and inform public policy. Outcomes data from multicenter trials have been used to support favorable recommendations from governmental agencies such as US Preventive Services Task Force and coverage and payment policy decisions from the Centers for Medicare and Medicaid Services (CMS) (
      • Pisano ED
      • Gatsonis C
      • Hendrick E
      • et al.
      Diagnostic performance of digital versus film mammography for breast-cancer screening.
      ,
      National Lung Screening Trial Research Team
      Reduced lung-cancer mortality with low-dose computed tomographic screening.
      ). The American College of Radiology (ACR) has a long history of supporting multicenter trials in diagnostic radiology and radiation oncology. These trials typically involve standardized protocol development, site management, the development of study data dictionaries and data collection and cleaning, independent interpretation of imaging findings and centralized support to collate, analyze and publish the results. Many of these trials have been funded by governmental agencies such the National Cancer Institute while others have been sponsored by industry and other institutions.
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