Rationale and Objectives
This study investigated the utility of histogram parameters derived from diffusion-weighted
imaging (DWI) for evaluating renal cell carcinoma (RCC) grading prior to surgery.
Materials and Methods
This retrospective study included 88 patients who were histopathologically diagnosed
with RCC and underwent magnetic resonance imaging (MRI) examinations. The patients
were divided into two groups as well-differentiated (Group 1) and poorly differentiated
(Group 2). Demographic data, preoperative MRI findings, MRI apparent diffusion coefficient
(ADC) histogram analyzes, operation types, postoperative histopathological data and
cancer stages of the patients were recorded. The histogram parameters of ADC values,
comprising the mean, minimum, maximum, 5th, 10th, 25th, 50th, 75th, 90th, and 95th
percentiles, as well as skewness, kurtosis, and variance, were calculated.
Results
The study included 59 males and 29 women with an average age of 56.21 ± 1.33 years.
There were 52 patients in Group 1 and 36 patients in Group 2. The ADCmin, ADCmean,
ADCmax, 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of ADC values of the
poorly differentiated group were all lower than those of the well-differentiated group.
ADCmin and the 5th percentile of ADC values, as well as ADCmean and the 10th, 25th,
50th, and 75th percentiles of ADC values, showed a statistically significant difference
(p < 0.05). The AUC, sensitivity, and specificity of the ADCmin value were 0.703,
56.3%, and 75.7%, respectively.
Conclusion
The present study indicated that histogram parameters generated from DWI were capable
of differentiating between high-grade and low-grade RCC.
Key Words
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Article info
Publication history
Published online: April 25, 2023
Accepted:
March 20,
2023
Received in revised form:
March 19,
2023
Received:
February 16,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved All rights reserved.
